Nanochip Technology for Single DNA Molecule Analysis and Human Genomic Polymorphism Analysis
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TL;DR
The nanochip technology coupled with AFM (atomic force microscopy) has been developed for the manipulation of single DNA molecule and will be applicable to the SNP analysis of single genomic DNA molecule.
Abstract
Human genome project has been moving on to the post genomic sequencing era including SNP (single nucleotide polymorphism) analysis, genomic function analysis, and proteome analysis. Towards post genomic sequencing era, laser confocal fluorescence detection system has been developed for the imaging of single DNA molecule migrating in the microchannel on a microchip. The separating process for a mixture of DNA fragments is visualised and the conditions for ultra fast separation of DNA fragments are optimised. The nanochip technology coupled with AFM (atomic force microscopy) has been developed for the manipulation of single DNA molecule. It will be applicable to the SNP analysis of single genomic DNA molecule.