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Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial

New England Journal of MedicinePublished 16 February 2005Open access
Robert S. Bresalier, Robert S. Sandler, Hui Quan, James A. Bolognese, Bettina Oxenius, Kevin Horgan
Citations2,487
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR

Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk, and cardiovascular mortality was similar in the two groups.

Abstract

Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk.

Keywords

MedicineBiochemistry, Genetics and Molecular Biology