Highlights from Philadelphia: ISSCR 2008
Cell stem cellPublished 1 September 2008Open access
Marella de Bruijn, Hanna Mikkola, Hans‐Willem Snoeck, Gordon Keller
Citations1
SJR quartileQ1
SJR score9.31
SNIP3.29
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
More than 2700 stem cell researchers from 44 different countries attended the 6th ISSCR Annual Meeting in Philadelphia from June 11 to 14, 2008 and presented in 1150 posters.
Abstract
More than 2700 stem cell researchers from 44 different countries attended the 6th ISSCR Annual Meeting in Philadelphia from June 11 to 14, 2008. The meeting covered a wide range of topics discussed in 7 plenary and 16 concurrent sessions and presented in 1150 posters.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
CellInduction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
26,520 Citations2006Kazutoshi Takahashi, Shinya Yamanaka
Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
CellDifferentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development
1,726 Citations2008Charles E. Murry, Gordon Keller
ScienceSelective Blockade of MicroRNA Processing by Lin28
1,438 Citations2008Srinivas R. Viswanathan, George Q. Daley +1 more
The results identify Lin28 as a negative regulator of miRNA biogenesis and suggest that Lin28 may play a central role in blocking miRNA-mediated differentiation in stem cells and in certain cancers.
Annual Review of MedicineCancer Stem Cells: Models and Concepts
1,280 Citations2006Piero Dalerba, Robert W. Cho +1 more
The biological basis and the therapeutic implications of the stem cell model of cancer, first developed in human myeloid leukemias, is reviewed, which is today being extended to solid tumors, such as breast and brain cancer.
NatureWnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
1,069 Citations2007Mayumi Ito, Zaixin Yang +5 more
It is shown that, after wounding, hair follicles form de novo in genetically normal adult mice, and these remarkable regenerative capabilities of the adult support the notion that wounding induces an embryonic phenotype in skin, and that this provides a window for manipulation of hair follicle neogenesis by Wnt proteins.
ScienceGeneration of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
1,040 Citations2008Takashi Aoi, Kojiro Yae +6 more
Genetic lineage tracings suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required.
Nature ImmunologyAcute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
974 Citations2004Kristin J. Hope, Liqing Jin +1 more
Heterogeneity in LSC self-renewal potential supports the hypothesis that they derive from normal HSCs, and the existence of multiple stem cell classes shows the need for LSC-targeted therapies.
CellStepwise Reprogramming of B Cells into Macrophages
934 Citations2004Huafeng Xie, Min Ye +2 more
Observations indicate that C/EBPalpha and beta remodel the transcription network of B cells into that of macrophages through a series of parallel and sequential changes that require endogenous PU.1.
Cell stem cellSequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells
817 Citations2008Tobias Brambrink, Ruth K. Foreman +5 more
Using inducible constructs derived induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs) and found that transgene silencing is a prerequisite for normal cell differentiation, a step toward understanding some of the molecular events governing epigenetic reprogramming.
CellDirect Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency
812 Citations2008Jacob H. Hanna, Styliani Markoulaki +11 more
This study provides definite proof for the direct nuclear reprogramming of terminally differentiated adult cells to pluripotency through transgenic and inducible expression of transcription factors.
Cell stem cellGlobal Transcription in Pluripotent Embryonic Stem Cells
698 Citations2008Sol Efroni, Radharani Duttagupta +11 more
It is proposed that global transcription is a hallmark of pluripotent ESCs, contributing to their plasticity, and that lineage specification is driven by reduction of the transcribed portion of the genome.
Genes & DevelopmentHuman ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
679 Citations2008Yechiel Elkabetz, Georgia Panagiotakos +4 more
It is proposed that R-NSCs represent the first characterized NSC stage capable of responding to patterning cues that direct differentiation toward region-specific neuronal fates, and offer new tools for harnessing the differentiation potential of human ESCs.
Cell stem cellLong-Term Propagation of Distinct Hematopoietic Differentiation Programs In Vivo
634 Citations2007Brad Dykstra, David G. Kent +7 more
CirculationDirected and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
474 Citations2008Genta Narazaki, Hideki Uosaki +6 more
The differentiation properties of iPS cells are almost completely identical to those of ES cells, which would greatly contribute to a novel understanding of i PS cell biology and the development of novel cardiovascular regenerative medicine.
CellHighly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles
468 Citations2008Massimiliano Cerletti, Sara Jurga +5 more
The presence in adult skeletal muscle of prospectively isolatable muscle-forming stem cells is indicated and the efficacy of myogenic stem cell transplant for treating muscle degenerative disease is demonstrated.
DevelopmentPivotal roles for eomesodermin during axis formation,epithelium-to-mesenchyme transition and endoderm specification in the mouse
284 Citations2008Sebastian J. Arnold, Ulf Krister Hofmann +2 more
It is established that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse.
Nature Reviews GeneticsGenetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation
280 Citations2008Kenneth S. Zaret
Understanding how tissue programming can be reversed and how intrinsic regenerative capacities are determined should facilitate the discovery of the basis of cellular plasticity and aid in the targeted programming and growth of stem cells.
Proceedings of the National Academy of SciencesIdentification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties
257 Citations2007Michelle B. Bowie, David G. Kent +5 more
The magnitude and timing of changes in the self-renewal properties and differentiated cell outputs of transplanted HSCs obtained from different sources during development point to the existence of a previously unrecognized, intrinsically regulated master switch that effects a developmental change in key HSC properties.
Cell stem cellEstablishment of Endoderm Progenitors by SOX Transcription Factor Expression in Human Embryonic Stem Cells
216 Citations2008Cheryle A. Séguin, Jonathan S. Draper +2 more
It is demonstrated that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonicendoderm and definitive endoderman progenitor cells, respectively.
CellRonin Is Essential for Embryogenesis and the Pluripotency of Mouse Embryonic Stem Cells
202 Citations2008Marion Déjosez, Joshua S. Krumenacker +6 more
A candidate pluripotency factor, Ronin, that possesses a THAP domain, which is associated with sequence-specific DNA binding and epigenetic silencing of gene expression is described, which suggests an epigenetic mechanism of gene repression in pluripotent cells.
NeuronRegulation of Motor Neuron Specification by Phosphorylation of Neurogenin 2
138 Citations2008Yongchao Ma, Mi Ryoung Song +8 more
Evidence is provided that two conserved serine residues on the bHLH factor neurogenin 2 (Ngn2), S231 and S234, are phosphorylated during motor neuron differentiation, which facilitates the interaction of Ngn2 with LIM homeodomain transcription factors to specify motor neuron identity.
CellSmall RNAs: Keeping Stem Cells in Line
109 Citations2008Bradford Stadler, Hannele Ruohola‐Baker
This work focuses on the role of small regulatory RNAs in the maintenance and pluripotency of stem cells and their role in RNA silencing.
Current Opinion in Genetics & DevelopmentChromatin state maps: new technologies, new insights
82 Citations2008Eric M. Mendenhall, B Bernstein
Chromatin state maps provide a rich resource for understanding chromatin at a 'systems level', and a starting point for mechanistic studies aimed at defining epigenetic controls that underlie development.
