Competing on the edge
Trends in NeurosciencesPublished 1 June 2002
Massimo Scanziani
Citations285
SJR quartileQ1
SJR score4.73
SNIP3.68
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TL;DR
A new study focusing on glutamate-mediated transmission in the cerebellum describes the specific role of neuronal transporters in modulating the access of glutamate to extrasynaptic metabotropic glutamate receptors, and reveals important consequences of Extrasynaptic signaling on synaptic plasticity.
Abstract
Fast-acting neurotransmitters can exit the synaptic cleft and bind to extrasynaptic receptors. This process is modulated by transmitter uptake mechanisms (transporters). A new study focusing on glutamate-mediated transmission in the cerebellum describes the specific role of neuronal transporters in modulating the access of glutamate to extrasynaptic metabotropic glutamate receptors, and reveals important consequences of extrasynaptic signaling on synaptic plasticity.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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