IN-VIVO DEMONSTRATION OF REDUCED BENZODIAZEPINE RECEPTOR BINDING IN HUMAN EPILEPTIC FOCI
The LancetPublished 1 October 1988
Ivanka Savic, Per E. Roland, Göran Sedvall, A. Persson, Stefan Pauli, L. Widén
Citations367
SJR quartileQ1
SJR score12.11
SNIP22.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The results demonstrate the potential of the BZ receptor as a biochemical marker for display of epileptic foci by PET, and strengthen the hypothesis that inhibitory mechanisms are disturbed in the epileptic focus.
Abstract
Ten patients with partial epilepsy and five healthy controls had positron emission tomography (PET) of the brain after intravenous administration of the 11C-labelled benzodiazepine (BZ) receptor ligand 'Ro-15 1788'. In all ten patients BZ receptor binding was significantly lower in the epileptic focus than in the contralateral homotopic reference region and the remaining neocortex. No asymmetries in BZ receptor binding were observed between homotopic reference regions in the controls or the non-epileptic regions of patients. These results demonstrate the potential of the BZ receptor as a biochemical marker for display of epileptic foci by PET, and also strengthen the hypothesis that inhibitory mechanisms are disturbed in the epileptic focus.
Keywords
MedicineNeuroscience
Southern Medical JournalEPILEPSY AND THE FUNCTIONAL ANATOMY OF THE HUMAN BRAIN
4,031 Citations1954Wilder Penfield, Herbert H. Jasper
Epilepsy and the Functional Anatomy of the Human Brain by Wilder Penfield;Herbert Jasper DjVu, ePub, doc, txt, PDF forms.
ScienceBenzodiazepine Receptor: Demonstration in the Central Nervous System
1,707 Citations1977H Möhler, Toshikazu Okada
Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency, and binding to the receptor is stereospecific.
ScienceQuantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET
842 Citations1986Lars Farde, Håkan Hall +2 more
Studies of [11C]raclopride binding indicate that clinically effective doses of chemically distinct neuroleptic drugs result in 85 to 90 percent occupancy of D2 dopamine receptors in the putamen of schizophrenic patients.
Electroencephalography and Clinical NeurophysiologyEpilepsy and the functional anatomy of the human brain
781 Citations1954H Gastaut
ScienceInhibitory, GABAergic Nerve Terminals Decrease at Sites of Focal Epilepsy
348 Citations1979Charles E. Ribak, A. Basil Harris +2 more
Annals of NeurologyMagnetic resonance imaging in temporal lobe epilepsy: Pathological correlations
333 Citations1987Ruben Kuzniecky, Vincent de La Sayette +8 more
Results indicate that MRI is a sensitive technique for localizing foreign‐tissue lesions, mesial temporal sclerosis, and gliosis in patients with intractable temporal lobe seizures.
Journal of Computer Assisted TomographyHead Fixation Device for Reproducible Position Alignment in Transmission CT and Positron Emission Tomography
315 Citations1981M Bergstr m, J Bo thius +4 more
A head-positioning device allowing accurate position transference between computed tomography and positron emission tomography is described, and the coordinates of an anatomic structure may be determined and transferred between the two images.
ScienceDiazepam-Binding Inhibitor: A Neuropeptide Located in Selected Neuronal Populations of Rat Brain
232 Citations1985Hannu Alho, E. Costa +4 more
An endogenous polypeptide of rat brain has been identified that is capable of displacing 1,4-benzodiazepines and the esters of the 3-carboxylic acid derivatives of beta-carbolines from their specific synaptic binding sites, and is termed diazepam-binding inhibitor (DBI).
Molecular and Cellular BiochemistryThe GABA postsynaptic membrane receptor-ionophore complex
206 Citations1981Richard W. Olsen
Available evidence suggests that the GABA receptor-ionophore system mediates many of the actions of numerous excitatory and depressant drugs showing a variety of pharmacological effects.
NeurologyLocal cerebral metabolism during partial seizures
205 Citations1983Jerome Engel, David E. Kuhl +3 more
Ictal hypermetabolism may exceed six times the interictal rate and could represent activation of excitatory or inhibitory synapses in the epileptogenic region and its projection fields.
Journal of Psychiatric ResearchImaging of [11C]-labelled RO 15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography
173 Citations1985A. Persson, E. Ehrin +6 more
The results demonstrate that [11C] Ro 15-1788 should be a valuable tool for quantitative analyses of benzodiazepine receptor characteristics and receptor occupancy in the brain of patients with neuropsychiatric disorders.
European Journal of PharmacologyKinetics and displacements of [11C]RO 15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography
170 Citations1985Yves Samson, P. Hantraye +4 more
The brain regional distribution and kinetics of RO 15-1788, a benzodiazepine (BZD) antagonist labeled with 11C was studied by time-of-flight positron tomography after intravenous injection in four normal human volunteers to suggest that [11C]RO may be useful for in vivo mapping of human brain BZD receptors using positrons tomography.
Journal of Cerebral Blood Flow & MetabolismRegional Specific Binding of [ <sup>11</sup> C]RO 15 1788 to Central Type Benzodiazepine Receptors in Human Brain: Quantitative Evaluation by PET
122 Citations1988Sabina Pappatà, Yves Samson +4 more
A simple method to estimate the specifically bound 11C-RO 15 1788 regionally in a single PET study is proposed, using the data from the full-saturation studies as a stable estimate of the nondisplaceable radioligand concentration.
Brain ResearchNeurotransmitter, receptor and biochemical changes in monkey cortical epileptic foci
121 Citations1981Roy A.E. Bakay, A. Basil Harris
Epilepsy appears to be a multifactoral disorder with multiple neuroreceptor abnormalities, the most notable of which are the destruction of GABAergic neurons and GABA receptors.
Human Psychopharmacology Clinical and ExperimentalSaturation analysis of specific <sup>11</sup>C Ro 15‐1788 binding to the human neocortex using positron emission tomography
86 Citations1989A. Persson, Stefan Pauli +5 more
The method described should be useful for studying regional differences in benzodiazepine receptor characteristics in the living human brain in healthy subjects and neuropsychiatric disorders, and also in relation to treatment with drugs interacting with benzidiazepine receptors.
International Journal of Nuclear Medicine and BiologyAlterations in biodistribution of [3H]ro 15-1788 in mice by acute stress: Possible changes in in vivo binding availability of brain benzodiazepine receptor
34 Citations1985Osamu Inoue, Yoshio Akimoto +2 more
Significant changes in biodistribution of carrier-free [3H]Ro 15-1788 were observed in stress-loaded mice, which strongly indicated that in vivo binding availability of Bz receptor in the brain was rapidly and reversibly reduced by acute stress.
Journal of Neurology Neurosurgery & PsychiatryCorrelations between cerebral blood flow variations and clinical parameters in temporal lobe epilepsy: an interictal study.
33 Citations1987Jean Valmier, J. Touchon +3 more
Regional cerebral blood flow measurements were determined by the intravenous Xenon 133 technique in 80 patients suffering from temporal lobe epilepsy and differences were found in the rCBF decrease between left and rightporal lobe epilepsy.
NeurologyBenzodiazepine receptor binding is not altered in human epileptogenic cortical foci
23 Citations1986Allan L. Sherwin, Elizabeth Matthew +2 more
No differences in receptor density (Bmax) or affinity (Kd) were observed when epileptic foci were compared with nonspiking cortex when benzodiazepine binding in cortical tissues was measured.