Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis

The LancetPublished 1 October 2000

Natasha Coyle, Ian Jones, Emma Robertson, Corinne Lendon, Nick Craddock

DOI10.1016/s0140-6736(00)02877-4

Source URL

Citations88

SJR quartileQ1

SJR score12.11

SNIP22.72

TL;DR

Significant evidence is reported that variation at the serotonin transporter gene exerts a substantial and important influence on susceptibility to episodes of severe psychiatric disturbance in parous females with bipolar disorder.

Abstract

Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important (population attributable fraction=69%) influence on susceptibility to such episodes.

Keywords

MedicineBiochemistry, Genetics and Molecular Biology

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