Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease
The American Journal of CardiologyPublished 28 January 2004
Ivana Antelmi, Rogério Silva de Paula, Alexandre R. Shinzato, Carlos A. Peres, Alfredo José Mansur, César Grupi
Citations552
SJR quartileQ2
SJR score0.93
SNIP0.73
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TL;DR
HRV indexes decreased with increasing age, differed by gender, and were higher in patients with higher functional capacity, and no correlation was noted between HRV and body mass index.
Abstract
We studied the time- and frequency-domain indexes of heart rate variability (HRV) in 653 patients without any evidence of heart disease relative to age, gender, heart rate, body mass index, and functional capacity. There was an inverse correlation of HRV with heart rate (p <0.001). HRV indexes decreased with increasing age, differed by gender, and were higher in patients with higher functional capacity. No correlation was noted between HRV and body mass index.
Keywords
MedicineEngineering
European Heart JournalHeart rate variability: Standards of measurement, physiological interpretation, and clinical use
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American Journal of Human BiologyPhysical Status: The Use and Interpretation of Anthropometry. Report of a WHO Expert Committee
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The American Journal of MedicineDifferential changes of autonomic nervous system function with age in man
450 Citations1983Michael Pfeifer, Clarice R. Weinberg +4 more
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444 Citations1995J. Thomas Bigger, Joseph L. Fleiss +4 more
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Annals of Internal MedicineStress Testing: Principles and Practice.
378 Citations1988
History of stress testing cardiovascular and pulmonary responses to exercise extra-cardiac effects of exercise physiology of cardiac ischemia stress testing protocol ECG patterns and their significance rhythm and conduction disturbances in stress testing stress testing in women sports medicine and rehabilitation paediatric exercise testing metabolic abnormalities and drugs.
Journal of the American College of CardiologyDeterminants of heart rate variability
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Age and heart rate were the major determinants of all three selected heart rate variability measures (partial R2 values 0.125 to 0.389), and Normative reference values for all eight heart rates variability measures are presented.
European Heart JournalHeart rate variability and heart rate in healthy volunteers. Is the female autonomic nervous system cardioprotective?
344 Citations1998Dirk Ramaekers
Cardiac autonomic modulation as determined by heart rate variability, is significantly lower in healthy women compared to healthy men, and this apparently paradoxical finding may be explained by lower sympathetic activity (low frequency power) in women.
Cardiovascular ResearchEarly and late effects of exercise and athletic training on neural mechanisms controlling heart rate
283 Citations1993Raffaello Furlan, S. Piazza +5 more
The cardiac sympathetic excitation outlasting heavy dynamic exercise may explain the coexistence of training bradycardia with signs of enhanced sympathetic activity in trained champion athletes.
American Journal of Physiology-Heart and Circulatory PhysiologyAging of modulation of heart rate
209 Citations1987Daniel C. Shannon, D. W. Carley +1 more
It is concluded that the influence of the two major mechanisms that modulate heart rate decline at significantly different rates with aging.
American Journal of Physiology-Heart and Circulatory PhysiologyDiurnal heart rate variability in healthy subjects: effects of aging and sex difference
145 Citations1996Yuzo Yamasaki, Mineo Kodama +7 more
Findings from frequency domain analysis of a Holter electrocardiogram record can help elucidate the diurnal profile of cardiac nerve function and how it is affected by aging and sex difference.
Journal of the Autonomic Nervous SystemAutonomic control of cardiac chronotropic function in man as a function of age: assessment by power spectral analysis of heart rate variability
125 Citations1991O. V. Korkushko, V. B. Shatilo +2 more
Different ratios between the sympathetic and the parasympathetic influences upon heart rate control in relation to age are demonstrated.
European Heart JournalSpectral components of short-term RR interval variability in healthy subjects and effects of risk factors
87 Citations1994H. Mølgaard, Kjeld Hermansen +1 more
Gender, age smoking and physical training level have a significant impact on the power and centre frequency of the HF and LF components, and these effects must be addressed in investigations on autonomic balance.
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PubMedControl of heart rate during exercise in health and disease.
53 Citations1996Linda C. Gallo, Benedito Carlos Maciel +6 more
Physiological blockade of sympathetic and parasympathetic efferent nerves was used to demonstrate differences in time constants and power-dependent relative participation of each division of the autonomic nervous system, as predominant mechanisms responsible for the tachycardia occurring during dynamic exercise.
PubMedSympathetic and parasympathetic changes in heart rate control during dynamic exercise induced by endurance training in man.
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