Can it work? Does it work? Is it worth it?
BMJPublished 11 September 1999Open access
Brian Haynes
Citations394
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Clinical trials typically select patients who are carefully diagnosed; are at highest risk of adverse outcomes from the disease in question; lack other serious illnesses; and are most likely to follow and respond to the treatment of interest.
Keywords
Immunology and MicrobiologyAgricultural and Biological Sciences
New England Journal of MedicineControversy in Counting and Attributing Events in Clinical Trials
411 Citations1979David L. Sackett, Michael Gent
An attempt is made to establish a procedure to estimate the number of events in a randomized clinical trial and to determine which treatment should be blamed for these events.
The LancetCost-effectiveness of malaria control in sub-Saharan Africa
277 Citations1999Catherine Goodman, P. G. Coleman +1 more
Using mathematical models to calculate cost-effectiveness ratios for the main prevention and treatment interventions in sub-Saharan Africa, it is found that a package of interventions to decrease the bulk of the malaria burden is not, however, affordable in very-low-income countries.
BMJMultifaceted shared care intervention for late life depression in residential care: randomised controlled trial Commentary: Beyond the boundary for a randomised controlled trial?
128 Citations1999Robert H. Llewellyn-Jones, Karen A. Baikie +6 more
The outcome of depression among elderly people in residential care can be improved by enhancing the clinical skills of general practitioners and care staff and by providing depression related health education and activity programmes for residents.
American Journal of Tropical Medicine and HygieneEnvironmental Management: A Re-Emerging Vector Control Strategy
117 Citations1994Steven K. Ault
EM has been proven to be a successful approach to vector control in a number of places, and community participation has been effective in the suppression of dengue vectors in Mexico and the Dominican Republic.
American Journal of Tropical Medicine and HygieneMalaria Transmission at a New Irrigation Project in Sri Lanka: the Emergence of Anopheles annularis as a Major Vector
66 Citations1992Ranjan Ramasamy, Ruklanthi de Alwis +2 more
It is suggested that a change in the ecosystem from dry zone forest to irrigated cultivated land is the cause of the increased prevalence of An.
PubMedMalaria control in the Gezira-Managil Irrigated Scheme of the Sudan.
48 Citations1985A. A. El Gaddal, A. A. M. Haridi +2 more
A proposal is outlined for a rational strategy for malaria control in the Gezira-Managil Irrigated Scheme and the mosquito vector developed resistance to several insecticides.
PubMedMalaria, schistosomiasis, and intestinal helminths in relation to microdams in Tigray, northern Ethiopia.
40 Citations1998Tsegaye Alemayehu, Yemane Ye-Ebiyo +4 more
The widespread distribution of schistosomiasis and intestinal helminths, and the presence of malaria infection during the dry season confirm that microdams create favourable conditions for the transmission of these parasitic diseases.
