The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex
Annals of Internal MedicinePublished 15 February 1990
James O. Kahn, J. Davis Allan, Teri L. Hodges, Lawrence D. Kaplan, Carol J. Arri, Helen F. Fitch
Citations132
SJR quartileQ1
SJR score3.38
SNIP3.27
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TL;DR
At the dose levels used in this study, rCD4 appears safe and well tolerated, and serum concentrations were achieved that were comparable to concentrations shown to have antiviral activity in vitro.
Abstract
At the dose levels used in this study, rCD4 appears safe and well tolerated. Serum concentrations of rCD4 were achieved that were comparable to concentrations shown to have antiviral activity in vitro. Further studies are indicated to determine whether rCD4 or related molecules will be useful in treating HIV infection.
Keywords
Immunology and MicrobiologyMedicine
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