Effects of benzodiazepines on sleep and wakefulness.
British Journal of Clinical PharmacologyPublished 1 February 1981Open access
Thomas Röth, Frank Zorick, J. Sicklesteel, Edward Stepanski
Citations31
SJR quartileQ1
SJR score1.16
SNIP1.20
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The differential effects of short and long acting benzodiazepines on sleeping and waking behaviour are discussed, with particular reference to hypnotic efficacy, and their effects on the structure of sleep and daytime function are discussed.
Abstract
The differential effects of short and long acting benzodiazepines on sleeping and waking behaviour are discussed, with particular reference to hypnotic efficacy, and their effects on the structure of sleep and daytime function.
Keywords
PsychologyMedicineNeuroscience
PsychopharmacologyThe effects of flurazepam, lorazepam, and triazolam on sleep and memory
135 Citations1980Thomas Roth, Kristyna M. Hartse +3 more
Results indicate that failure of memory consolidation rather than failure of retrieval is the most likely explanation for the morning memory loss and hypnotic drug properties, measured by latency to fall back asleep, affect memory consolidation.
Journal of Pharmaceutical SciencesBlood Level Profile in Man following Chronic Oral Administration of Flurazepam Hydrochloride
102 Citations1973S. A. Kaplan, J.A.F. de Silva +6 more
The blood level profile of flurazepam and its major metabolites was determined in man following the oral administration of 30 mg.
Life SciencesEffects of hypnotic drugs on memory
62 Citations1979Edward O. Bixler, Martin B. Scharf +3 more
It is suggested that when patients ingest certain benzodiazepine hypnotics before or at bedtime, there may be a decrement in memory retrieval of information acquired before sleep onset or during nocturnal awakenings.
Life SciencesClofilium1--a new antifibrillatory agent that selectively increases cellular refractoriness
52 Citations1979Mitchell I. Steinberg, Bryan B. Molloy
Clofilium is the most promising member in a new series of antifibrillatory agents to selectively prolong cardiac action potential duration (APD) and effective refractory period (ERP) and in normal superfused canine Purkinje fibers, cl ofilium prolonged APD and ERP by a maximum of 35%.
The Japanese Journal of PharmacologyPHARMACOLOGICAL STUDIES ON NEW POTENT CENTRAL DEPRESSANTS, 8-CHLORO-6-PHENYL-4H-s-TRIAZOLO [4, 3a] [1, 4] BENZODIAZEPINE (D-40TA) AND ITS 1-METHYL ANALOGUE (D-65MT)
43 Citations1971Ryoko Nakajima, Yomei TAKE +4 more
Two compounds, 8-chloro-6-phenyl-4H-s-triazolo and its 1-methyl analogue (D-65MT) were undergone more detailed pharmacological evaluation of effects on central nervous system, in comparison with other benzodiazepines and chlorpromazine.
British Journal of Clinical PharmacologyEFFECTS OF TEMAZEPAM, FLURAZEPAM ANDQUINALBARBITONE ON SLEEP: PSYCHOMOTOR AND COGNITIVE FUNCTION
36 Citations1979Thomas Röth, P Piccione +3 more
The results suggest that temazepam produces less residual effects and is shorter acting than quinalbarbitone and flurazepAm, and that subjective assessments of alertness were most affected by flurzepam, and by quinal barbitone 200 mg.