Cancer risks among BRCA1 and BRCA2 mutation carriers
British Journal of CancerPublished 1 January 2007Open access
Ephrat Levy‐Lahad, Eitan Friedman
Citations331
SJR quartileQ1
SJR score3.14
SNIP1.83
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TL;DR
BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates.
Abstract
BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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