Neuronal birthdate underlies the development of striatal compartments
Brain ResearchPublished 1 January 1987
Derek van der Kooy, Gord Fishell
Citations267
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix, and it is found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment.
Abstract
The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underlie pattern formation throughout the developing forebrain.
Keywords
MedicineNeuroscience
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