Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.
The Journal of Experimental MedicinePublished 1 July 1983Open access
Anne M. Glazier, P. J. Tutschka, Evan R. Farmer, George W. Santos
Citations278
SJR quartileQ1
SJR score5.83
SNIP1.99
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Lethally irradiated rats treated with cyclosporin A for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not.
Abstract
Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not. Syngeneic GVHD may be transferred to irradiated but not normal syngeneic recipients. Normal spleen cells fail to prevent the development or adoptive transfer of syngeneic GVHD.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Inflammation ResearchBiological effects of cyclosporin A: A new antilymphocytic agent
1,511 Citations1976J. F. Borel, Camille Feurer +2 more
Experimental evidence suggests that cyclosporin A affects an early stage of mitogenic triggering of the immunocompetent lymphoid cell, which contrasts with other immunosuppressives and cytostatic drugs in its weak myelotoxicity.
The Journal of ImmunologyCyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.
344 Citations1980E L Larsson
The Journal of ImmunologyEffect of cyclosporin A on human lymphocyte responses <i>in vitro</i>. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.
236 Citations1980Allan D. Hess, P. J. Tutschka
Results suggest that CsA treatment favors the induction of suppressor cell mechanisms as opposed to cytolytic effector cells in primary MLR, which may account for the ability of this drug to establish transplantation tolerance in vivo.
The Journal of ImmunologyEffect of cyclosporin A on human lymphocyte responses <i>in vitro</i>. III. CsA inhibits the production of T lymphocyte growth factors in secondary mixed lymphocyte responses but does not inhibit the response of primed lymphocytes to TCGF.
154 Citations1982Allan D. Hess, P. J. Tutschka +1 more
It was concluded that inhibition of secondary mixed lymphocyte responses by CsA may be due in part to the inhibition of TCGF production rather than the inhibited of the effect ofTCGF on mature cytotoxic T lymphocytes.
NatureCyclosporin A blocks receptors for HLA-DR antigens on T cells
139 Citations1981Ronald Palacios, Göran Möller
Results suggested that the HLA-DR antigens rendered resting T cells sensitive to IL-2 and participated actively in the production of the growth factor in the autologous mixed lymphocyte reaction.
NatureUse of cyclosporin A in allogeneic bone marrow transplantation in the rat
104 Citations1979P. J. Tutschka, William E. Beschorner +3 more
Cyclosporin A (Cs A), an undecapeptide of fungal origin, has been reported to have very profound antilymphocytic activities with very low degrees of myelotoxicity and seems to be a promising agent for use in clinical marrow transplantation.
The Journal of ImmunologyEffect of cyclosporin A on human lymphocyte responses <i>in vitro</i>. II. Induction of specific alloantigen unresponsiveness mediated by a nylon wool adherent suppressor cell.
78 Citations1981Allan D. Hess, P. J. Tutschka +1 more
TransplantationSUPPRESSOR CELLS IN TRANSPLANTATION TOLERANCE I. SUPPRESSOR CELLS IN THE MECHANISM OF TOLERANCE IN RADIATION CHIMERAS
60 Citations1981P. J. Tutschka, Allan D. Hess +2 more
Histoincompatible-complete radiation chimeras possess T lymphocytes in the spleen that specifically suppress donor to host mixed lymphocyte reactions and adoptively transfer suppression of GVHD to secondary hosts, suggesting that transplantation tolerance is not attributable to clonal deletion but the activity of nylon-wool-adherent T suppressor spleen cells.
Clinical Immunology and ImmunopathologySequential morphology of graft-versus-host disease in the rat radiation chimera
57 Citations1982William E. Beschorner, P. J. Tutschka +1 more
The Journal of Experimental MedicineRUNT DISEASE INDUCED IN NEONATAL MICE BY STERILE BACTERIAL VACCINES
29 Citations1964Richard D. Ekstedt, Edwin T. Nishimura
Germ-free ICR mice were much more resistant to the runting phenomenon than conventional animals of the same strain, but could be induced to runt by injection of the staphylococcal vaccine suspended in homologous antiserum.
TransplantationPROLONGATION OF RENAL ALLOGRAFT SURVIVAL IN THE RAT BY PRETREATMENT WITH DONOR ANTIGEN AND CYCLOSPORIN A
23 Citations1981WILLIAM P. HOMAN, Keryn A. Williams +2 more
Findings suggest that clonal deletion had not occurred in these pretreatment protocols, but that a shift in immunoregulatory mechanisms was responsible for the long survival of subsequent DA renal allografts.