Maintenance of peripheral dendrites of GABAergic neurons requires specific input
Brain ResearchPublished 1 July 1991
Robert Nitsch, Michael Frotscher
Citations53
SJR quartileQ2
SJR score0.85
SNIP0.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Persisting transneuronal changes in GABAergic hippocampal neurons following the removal of their entorhinal afferents may play a role in Alzheimer's disease since there is a severe degeneration of theEntorhino-hippocampal projection in this neurodegenerative disorder.
Abstract
This study demonstrates that the removal of a major hippocampal afferent system, the fibers from the entorhinal cortex, results in transneuronal changes in postsynaptic GABAergic inhibitory neurons. Following swelling of their distal segments, the peripheral dendrites of these cells retract from the termination zones of degenerating entorhinal fibers in the outer molecular layer of the fascia dentata and in stratum lacunosum-moleculare of the hippocampus proper. These dendritic alterations are long-lasting and do not seem to be restored by sprouting of other intact afferents. Persisting transneuronal changes in GABAergic hippocampal neurons following the removal of their entorhinal afferents may play a role in Alzheimer's disease since there is a severe degeneration of the entorhino-hippocampal projection in this neurodegenerative disorder.
Keywords
MedicineNeuroscience
Journal of Histochemistry & CytochemistryUse of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
14,259 Citations1981S M Hsu, Laurence Raine +1 more
The ABC method, which involves an application of biotin-labeled secondary antibody followed by the addition of avidin-biotin-peroxidase complex, gives a superior result when compared to the unlabeled antibody method.
ScienceAlzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation
2,272 Citations1984Bradley T. Hyman, Gary W. Van Hoesen +2 more
Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Principles of Neurology
1,720 Citations1977Raymond D. Adams, Maurice Victor
ScienceParvalbumin in Most γ-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex
744 Citations1986Marco R. Celio
With semithin frozen sections, it is possible to demonstrate that most GABA neurons in the rat somatosensory cortex contain the calcium-binding protein parValbumin and that parvalbumin is found virtually only in GABA neurons.
NeuroscienceA note on the use of picric acid-paraformaldehyde-glutaraldehyde fixative for correlated light and electron microscopic immunocytochemistry
571 Citations1982Péter Somogyi, Hiroshi Takagi
The buffered picric acid paraformaldehyde fixative has been supplemented with glutaraldehyde and used as primary fixative for the perfusion of rat brains and it is suggested that the procedure may be useful for electron-microscopic sampling of immunoreactive structures occurring infrequently over a large area or for the electron- microscopically classified neurons.
Brain ResearchGABAergic neurons containing the Ca2+-binding protein parvalbumin in the rat hippocampus and dentate gyrus
537 Citations1987Toshio Kosaka, Hironobu Katsumaru +3 more
The distribution of Ca2+-binding protein, parvalbumin (PV), containing neurons and their colocalization with glutamic acid decarboxylase (GAD) were studied in the rat hippocampus and dentate gyrus using immunohistochemistry.
Anterograde and Retrograde Transneuronal Degeneration in the Central and Peripheral Nervous System
458 Citations1970William Cowan
The etiological factors responsible for the atrophy or degeneration of neurons which have suffered no direct injury are still largely unknown, but the time seems opportune to review the now extensive literature on this subject.
Brain ResearchAn electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration
456 Citations1976Dee Ann Matthews, Carl W. Cotman +1 more
The extent and time course of degeneration is described and the nature of the reinnervation processes is described; degenerating entorhinal terminals behaved as a population which disappeared randomly at a rate dependent on the fraction of terminals present at any time.
Cell CalciumMonoclonal antibodies directed against the calcium binding protein parvalbumin
422 Citations1988Marco R. Celio, W. Baier +3 more
Twelve monoclonal antibodies (McAB) produced against carp-II parvalbumin recognize determinants conserved in fish, chicken, mouse, rat, monkey and human parValbumin and are shown to use in the qualitative detection of paravalbumin (PV) by immunohistochemistry, in the quantitation of parvalsbumin by radioimmunoassay and in the detection ofParvalbumIn on immunoblots.
Brain ResearchAn electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts
382 Citations1976Dee Ann Matthews, Carl W. Cotman +1 more
The authors' data indicate that granule cells retain a capacity even into adulthood to manufacture, position and assemble postsynaptic components of a synapse and, in concert with reactive afferents, form normal-appearing synapses.
The Journal of Comparative NeurologyThe process of reinnervation in the dentate gyrus of the adult rat: A quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis
255 Citations1983Oswald Steward, Sharon Vinsant
Terminal proliferation precedes reactive Synaptogenesis in the dentate gyrus by 2‐4 days, that terminal proliferation is essentially complete by 12 days while reactiveSynaptogenesis continues, and that multiple synapses arise at least in part as a result of a deformation of degenerating presynaptic processes rather than as a consequence of the induction of additional contacts on existing presynptic terminals.
NatureSpine Loss and Regrowth in Hippocampus following Deafferentation
197 Citations1974John G. Parnavelas, Gary Lynch +3 more
There is no data on whether spines are replaced when sprouting afferents invade deafferented dendritic zones, which is a critical question if the nature of the morphological reorganisation which follows lesions in the brain is to be understood.
The Journal of Comparative NeurologyDendritic reorganization in the denervated dentate gyrus of the rat following entorhinal cortical lesions: A Golgi and electron microscopic analysis
181 Citations1983Alfredo Cáceres, Oswald Steward
Electron microscopic analysis confirms the Golgi observations, indicating that the amount of neuropil occupied by dendritic shafts in the denervated zone is initially reduced and later recovers to values close to those observed in control animals.
Anatomy and EmbryologyThe parvalbumin-containing nonpyramidal neurons in the rat hippocampus
163 Citations1990Robert Nitsch, Eduardo Soriano +1 more
The calcium-binding protein parvalbumin is considered to be involved in the control of intracellular ion homeostasis of highly active inhibitory neurons, a subgroup of GABAergic neurons that has a target specificity for the cell body region.
Brain ResearchEntorhinal fibers form synaptic contacts on parvalbumin-immunoreactive neurons in the rat fascia dentata
98 Citations1989Frauke Zipp, Robert Nitsch +2 more
This study demonstrates that entorhinal fibers labeled by anterograde degeneration also terminate on parvalbumin-containing non-granule cells in the rat fascia dentata, providing evidence for a role of entorHinal fibers in feed-forward inhibition of the granule cells.