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Relapse of depression after rapid depletion of tryptophan

The LancetPublished 1 March 1997
KA Smith, C. G. Fairburn, Philip J. Cowen
Citations424
SJR quartileQ1
SJR score12.11
SNIP22.72

TL;DR

It is concluded that rapid lowering of brain serotonin function can precipitate clinical depressive symptoms in well, untreated individuals who are vulnerable to major depressive disorder.

Abstract

We conclude that rapid lowering of brain serotonin function can precipitate clinical depressive symptoms in well, untreated individuals who are vulnerable to major depressive disorder. The findings support a key role for deficient serotonin function in the aetiology of depression.

Keywords

MedicineNeuroscience