Influence of beta-blockers on melatonin release

Findings indicate that beta-blockers decrease melatonin release via specific inhibition of adrenergic beta1- and alpha1-receptors, and further clinical studies should investigate whether or not oral administration of melatonin might avoid this well-known side-effect of beta-blocking.

Abstract

These findings indicate that beta-blockers decrease melatonin release via specific inhibition of adrenergic beta1-receptors. Since lower nocturnal melatonin levels might be the reason for sleep disturbances, further clinical studies should investigate whether or not oral administration of melatonin might avoid this well-known side-effect of beta-blockers. The reason why (R,S)-carvedilol does not influence melatonin production remains to be determined.