Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans
GastroenterologyPublished 1 December 1998Open access
Ronnie Fass, Bruce D. Naliboff, L. Higa, Cindy Johnson, Anatoly Kodner, Julie Munakata
Citations297
SJR quartileQ1
SJR score7.20
SNIP5.04
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TL;DR
Chronic acid reflux by itself is not likely to play a role in reported esophageal hypersensitivity to distention in patients with noncardiac chest pain, and mechanosensitive and chemosensitive afferent pathways are differentially affected.
Abstract
Mild-to-moderate chronic tissue injury in gastroesophageal reflux disease differentially affects mechanosensitive and chemosensitive afferent pathways. Chronic acid reflux by itself is not likely to play a role in reported esophageal hypersensitivity to distention in patients with noncardiac chest pain.
Keywords
Medicine
Archives of NeurologyHandbook of Physiology.
10,386 Citations1960F. Plum
This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology.
GastroenterologyBasic and clinical aspects of visceral hyperalgesia
916 Citations1994Emeran A. Mayer, Gerald F. Gebhart
A model is proposed by which abdominal pain from chronic inflammatory conditions of the gut and functional bowel disorders such as noncardiac chest pain, nonulcer dyspepsia, and irritable bowel syndrome could develop by multiple mechanisms either alone or in combination.
GastroenterologyHealing and relapse of severe peptic esophagitis after treatment with omeprazole
786 Citations1988David J. Hetzel, John Dent +12 more
Omeprazole is a highly effective treatment for peptic esophagitis, and the 40-mg/day dosage produces endoscopic healing slightly more quickly than the 20-mg/, and the initial endoscopic gradings are of prognostic value.
PainVisceral pain: a review of experimental studies
600 Citations1990Timothy J. Ness, G. F. Gebhart
This paper proposes a definition of an adequate noxious visceral stimulus and speculate on spinal mechanisms of visceral pain, and reviews clinical and basic science research reports on visceral pain.
PainRatio scales of sensory and affective verbal pain descriptors
559 Citations1978Richard H. Gracely, Patricia McGrath +1 more
The ratio responses to the verbal descriptors in both experiments demonstrated specific functional relationships found for measurable psychophysical stimuli, which supports the validity of cross‐modality matched ratio scales of verval stimuli.
GastroenterologyRegional cerebral activity in normal and pathological perception of visceral pain
550 Citations1997DH Silverman, J. Munakata +4 more
The perception of acute rectal pain is associated with activation of the anterior cingulate cortex in healthy subjects, and patients with IBS show an aberrant brain activation pattern both during noxious rectal distention and during the anticipation ofrectal pain.
Annals of Internal MedicineEsophageal Testing of Patients with Noncardiac Chest Pain or Dysphagia
466 Citations1987Philip O. Katz, CHRISTINE B. DALTON +3 more
Manometric abnormalities were statistically commoner in patients with dysphagia, occurring in 53%.
Mayo Clinic ProceedingsA New Questionnaire for Gastroesophageal Reflux Disease
430 Citations1994G. Richard Locke, Nicholas J. Talley +2 more
The initial results suggest that this questionnaire is valid and should be applicable in population-based studies to assess gastroesophageal reflux disease.
GastroenterologyRepetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome
383 Citations1997J. Munakata, B Naliboff +6 more
In patients with IBS, repetitive stimulation of sigmoid splanchnic afferents results in the development of central sensitization manifested as hyperalgesia and increased viscerosomatic referral during rectal distention and as spontaneous rectosigmoid hyperalGESia in the absence of applied stimuli.
Digestive Diseases and SciencesAmbulatory 24-hour esophageal pH monitoring
326 Citations1988Gregory Wiener, Timothy M. Morgan +4 more
The large intrastudy variability in 24-hr total acid exposure may limit this test's usefulness as a measurement of therapeutic improvement in gastroesophageal reflux disease.
Journal of NeuroscienceA dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro
294 Citations1995Steen Kh, AE Steen +1 more
A major role of local acidosis in long lasting excitation and sensitization of cutaneous nociceptors has recently been demonstrated and this condition is mimicked in a rat skin-saphenous nerve preparation in vitro which allows direct application of chemicals to the isolated receptive fields at the corium side.
GutSymptoms and visceral perception in severe functional and organic dyspepsia
253 Citations1998Howard Mertz, S Fullerton +2 more
Alterations in the perception of gastric distension distinguishes between functional and organic dyspepsia, while symptoms do not.
Annals of Internal MedicineUnexplained Chest Pain: The Hypersensitive, Hyperreactive, and Poorly Compliant Esophagus
193 Citations1996Satish Sanku Chander Rao, Hans Gregersen +3 more
Impedance planimetry was used to determine whether a sub-group of patients with unexplained noncardiac chest pain has abnormal biomechanical esophageal muscle properties and abnormal esphageal sensory nerve function.
Comprehensive physiologySensory afferents from the gastrointestinal tract
182 Citations1989David Grundy, T Scratcherd
PainRectal afferent function in patients with inflammatory and functional intestinal disorders
179 Citations1996Charles N. Bernstein, Negar Niazi +6 more
It is demonstrated that chronic ileal inflammation is associated with increased thresholds for discomfort and greatly diminished systemic autonomic reflex responses, and patients with diarrhea‐predominant IBS show lowered thresholds for comfort associated withincreased autonomic responses.
Cells Tissues OrgansVegetative innervation of the esophagus. II. Intraganglionic laminar endings
133 Citations1975José Rodrigo, Carlos José Hernández +2 more
The intraganglionic laminar endings in the esophagus of the cat and the rhesus monkey show absolute equivalence between the results in both species from the morphological standpoint, and a possible afferent function is proposed.
Medical Entomology and ZoologyBasic and Clinical Aspects of Chronic Abdominal Pain
128 Citations1993Emeran A. Mayer, Helen E. Raybould
Part 1: Functional Bowel Disorders - Myths and Reality (E.A. Mayer).
PainViscerosomatic convergence onto feline spinal neurons from esophagus, heart and somatic fields: effects of inflammation
99 Citations1992David W. Garrison, Margaret J. Chandler +1 more
The data supported the hypotheses thatferred pain from the distal esophagus resulted from activation of the same spinal neurons by visceral and somatic input, and pain originating from the Distal Esophagus and heart might be difficult to distinguish because of viscerosomatic and viscerovisceral convergence onto the same spine neurons.
GastroenterologySensitization to painful distention and abnormal sensory perception in the esophagus
87 Citations1995Anand J. Mehta, John de Caestecker +2 more
In patients with negative results of esophageal tests and in controls, the pain threshold to balloon distention is lowered by acid, which implies that pain receptors may already be sensitized.
Cells Tissues OrgansVegetative innervation of the esophagus
76 Citations1976Juan Ángel Pedrosa, Carlos José Hernández +2 more
The comparative results between cat and rhesus monkey show differences in the distribution and number of endings of tela submucosa and tunica muscularis in the esophagus, and a sensory functional significance is proposed and discussed.
Cells Tissues OrgansVegetative innervation of the esophagus. III. Intraepithelial endings
74 Citations1975José Rodrigo, Carlos José Hernández +2 more
Intraepithelial fibers do occur in the mucosa of the esophagus, as demonstrated by the osmium tetroxide-zinc iodide method in cats and rhesus monkeys, and they may be functionally regarded as structures of a sensory character.
Journal of NeurophysiologyDifferential sensitivity to bradykinin of esophageal distension-sensitive mechanoreceptors in vagal and sympathetic afferents of the opossum
67 Citations1992Jyoti N. Sengupta, J. K. Saha +1 more
The sensitivity to bradykinin (BK) administered systemically (1-300 micrograms/kg) was tested in LTM, WDRMN, and HTMN fibers, and eight fibers were insensitive to BK, revealing two types of fibers: a wide-dynamic-range mechanonociceptor (WDRMN) and a "high-threshold mechan onocceptor" (HTMN).
GutEffect of famotidine on oesophageal sensitivity in gastro-oesophageal reflux disease.
62 Citations1994J M Marrero, John de Caestecker +1 more
Oesophageal sensitivity to acid is reduced by famotidine independent of and effect on oesophagitis; the effect wanes one to four weeks after the end of treatment and correlates with change in heartburn score.
Journal of NeurophysiologyCharacterization of responses of T2-T4 spinal cord neurons to esophageal distension in the rat
59 Citations1993I. Euchner-Wamser, Jyoti N. Sengupta +2 more
Three hundred fifty neurons in the T2-T4 spinal segments of 38 intact, pentobarbital sodium-anesthetized, pancuronium-paralyzed male rats were examined for somatic receptive fields and responses to midthoracic esophageal distension (ED), finding stable and reproducible responses of neurons excited by ED.
Neurogastroenterology & MotilityThe effect of octreotide on human gastric compliance and sensory perception
46 Citations1995Howard Mertz, John H. Walsh +2 more
It is suggested that at low distension volumes, OCT in the dosage used has a direct inhibitory effect on afferents mediating innocuous gastric sensations, and the hyperalgesic effect observed during phasic distention may be secondary to OCT's inhibitoryEffect on the gastric accommodation reflex.
European Journal of Gastroenterology & HepatologyMucosal acid exposure sensitizes a subset of normal subjects to intra-oesophageal balloon distension
34 Citations1996Paolo L. Peghini, Brian Johnston +2 more
Individuals showing mucosal acid sensitivity have a lower threshold for mechanoreceptor stimulation after acid exposure, and no change of the threshold for sensation occurred in either of these groups after acid infusion.
PubMedAcid infusion does not affect intraesophageal balloon distention-induced sensory and pain thresholds.
22 Citations1997DeVault Kr
It is concluded that infused acid has no effect on pain threshold and has a nonspecific effect on sensory threshold induced by esophageal balloon distention.
GutSensational developments in the irritable bowel.
15 Citations1996Bruce D. Naliboff, Emeran A. Mayer
The interesting study by Louvel et al in this issue illustrates both the progress and the continuing problems that characterise current studies on the perception of experimental gastrointestinal distension.
Is Helicobacter pylori a Cause of Nonulcer Dyspepsia?
10 Citations1990Nicholas J. Talley
The majority of patients who present to physicians with chronic or recurrent dyspepsia, however it is defined, do not have a peptic ulcer or definite evidence of organic disease when investigated; such patients have been generally labelled as suffering from nonulcer dyspePSia (NUD).