In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide
Prostaglandins Leukotrienes and Essential Fatty AcidsPublished 3 April 2004
S. R. De Vriese, A. Christophe, Michaël Maes
Citations111
SJR quartileQ2
SJR score0.86
SNIP0.76
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The results show that there is a true seasonality in long-chain PUFAs, such as AA, EPA and DHA, and suggest that the seasonability in PUfAs may be related to the incidence of violent suicide and the expression of the serotonin transporter complex.
Abstract
Our results show that there is a true seasonality in long-chain PUFAs, such as AA, EPA and DHA. The results suggest that the seasonality in PUFAs may be related to the incidence of violent suicide and the expression of the serotonin transporter complex.
Keywords
NeuroscienceEnvironmental Science
Progress in Lipid ResearchEssential fatty acids in growth and development
930 Citations1991Sheila M. Innis
The LancetFish consumption and major depression
897 Citations1998Joseph R. Hibbeln
The hypothesis that a high consumption of fish could be correlated with a lower annual prevalence of major depression was tested and the direction and power of the correlation between apparent fish consumption and major depression did not show that fish consumption can cause differences in the prevalence ofmajor depression or that eating fish or fish oils are useful in treatment.
Biological PsychiatryDepletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients
581 Citations1998Malcolm Peet, Brendan Murphy +2 more
These findings suggest that RBC membranes in depressive patients show evidence of oxidative damage, and implications for the etiology and treatment of depression are discussed.
LipidsArachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression
477 Citations1996P. B. Adams, Sheryl Lawson +2 more
It is suggested that the findings of this study provide a basis for studying the effect of the nutritional supplementation of depressed subjects, aimed at reducing the AA/EPA ratio in tissues and severity of depression.
Psychiatry ResearchLowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients
452 Citations1999Michaël Maes, Armand Christophe +4 more
There is an abnormal metabolism of omega3 PUFAs in depression and the FA alterations in depression are related to the inflammatory response in that illness; and the disorders may persist despite successful antidepressant treatment.
Journal of Affective DisordersFatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6C20:5ω3 ratio in cholesteryl esters and phospholipids
422 Citations1996Michaël Maes, R.S. Smith +4 more
An abnormal intake or metabolism of essential fatty acids in conjunction with decreased formation of cholesteryl esters in major depression is suggested.
annales de biologie animale biochimie biophysiqueThe metabolism and availability of essential fatty acids in animal and human tissues
230 Citations1994J. Bézard, JP Blond +2 more
Liver is one of the most active organs and its role is critical in providing less active tissues, particularly the brain, with long-chain PUFA secreted in VLDL (very low density lipoprotein).
American Journal of Clinical NutritionThe role of essential fatty acids in neural development: implications for perinatal nutrition
227 Citations1993Michael A. Crawford
Proper provision should be made to protect the AA and DHA status of both term and preterm infants to ensure optimum conditions for the development of membrane-rich systems such as the brain, nervous, and vascular systems.
American Journal of Clinical NutritionThe role of essential fatty acids in neural development: implications for perinatal nutrition
203 Citations1993M.A. Crawford
American Journal of PsychiatrySeasonality in violent suicide but not in nonviolent suicide or homicide
199 Citations1993Michaël Maes, Paul Cosyns +3 more
Seasonality in suicide is determined by significant circannual rhythms in violent suicides, which differ between younger and elderly persons, and there was a significant seasonality for suicide but not homicide.
Archives of General PsychiatrySeasonal Variation in Plasma L-Tryptophan Availability in Healthy Volunteers
169 Citations1995Michaël Maes
The results show a bimodal seasonal pattern in the availability of plasma L-tryptophan that matches seasonal patterns in the prevalence of violent suicide in the local population and depression in other studies.
Psychiatry ResearchAnalysis of seasonal fluctuations of CSF monoamine metabolites and neuropeptides in normal controls: Findings with 5HIAA and HVA
141 Citations1988Timothy D. Brewerton, Wade H. Berrettini +2 more
The data support a growing body of evidence indicating a substantial seasonal effect on the serotonin system and suggest that any group analysis of CSF 5HIAA, and perhaps HVA, should take into account circannual variability.
Acta Psychiatrica ScandinavicaSuicidal behavior, impulsiveness and serotonin
134 Citations1988A. Roy, M. Linnoila
The authors review the accumulating evidence from preclinical, clinical and postmortem studies suggesting that abnormality in serotonin systems may be associated with both attempts at suicide and aggression towards others and inanimate objects.
Neuropharmacology[3H]Paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: Effect of administration of various antidepressant treatments
123 Citations1993Sharon C. Cheetham, Jean Viggers +3 more
It would, therefore, appear that antidepressant therapy does not produce adaptive changes in 5-HT uptake sites and the view that [3H]paroxetine binds to a single site which corresponds to the 5- HT uptake site is supported.
Journal of Internal Medicinen‐6 and n‐3 fatty acids during early human development
105 Citations1989Michael A. Crawford, Wendy Doyle +4 more
Interestingly high levels of the Mead acid were found, with the highest appearing in the artery from the baby with the lowest birth weight, which probably indicates a remarkable thirst for long chain n‐6 and n‐3 fatty acids for fetal brain development.
PsychopharmacologyHigh affinity binding of3H-paroxetine and3H-imipramine to rat neuronal membranes
98 Citations1986Erling T. Mellerup, Per Plenge
The results indicated that the3H-paroxetinebinding site is identical in neuronal membranes and in platelet membranes; this binding site is probably located on the serotonin transport mechanism.
Acta Psychiatrica ScandinavicaSeasonality in severity of depression: relationships to suicide and homicide occurrence
77 Citations1993Michaël Maes, Herbert Y. Meltzer +2 more
There were significant correlations between the weekly average in severity of illness and the chronograms of suicide (positively) and homicide (negatively) occurrence in Belgium.
Clinica Chimica ActaNew method for the determination of the fatty acid pattern of serum lipid classes
68 Citations1967A. Christophe, F. Matthijs
After extraction the serum lipids are separated by a new thin-layer chromatography method and the fatty acid pattern of each class is determined by gas chromatography.
Journal of Affective DisordersSeasonal variations in biochemical factors related to depressive illness
64 Citations1980Cynthia Swade, Alec Coppen
Biochemical variates that may be related to depressive illness have been shown to vary significantly according to the season, and may account for the seasonal variation in depression and suicide that have been reported by many investigators.
European PsychiatryBiochemical, metabolic and immune correlates of seasonal variation in violent suicide: a chronoepidemiologic study
57 Citations1996Michaël Maes, Simon Scharpé +5 more
The annual rhythm in violent suicide rate is highly significantly synchronized with the annual rhythms in L-TRP, cholesterol, calcium, magnesium, CD20+ B cells, and CD4+/CD8+ ratio; the mean peak (violent suicide, [3H]paroxetine binding) or nadir (all other variables) occurs around 3 May.
LipidsOxidative stability of low density lipoproteins and vitamin E levels increase in maternal blood during normal pregnancy
38 Citations2001S. R. De Vriese, Marc Dhont +1 more
The major finding of this study is the increased oxidative resistance of LDL with progressing gestation.
NeuropsychopharmacologySeasonal Variation in Platelet [3H]Paroxetine Binding in Healthy Volunteers Relationship to Climatic Variables
28 Citations1996Peter D'Hondt
There was a statistically highly significant seasonal pattern in [3H]paroxetine binding to platelets with significant annual, 4-monthly, and bimonthly rhythms, which were expressed as a group phenomenon.
International Journal of BiometeorologySpectral resolution of cardio-circulatory variations in men measured by autorhythmometry over 2 years
22 Citations1990F. De Meyer, P Vogelaere
An analogue of the periodogram method for unequally spaced data is presented with a view to resolving the frequency structure of the observations and it is shown how the between-plot random variations can be incorporated into the multiple harmonic regression model.
