Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells
NaturePublished 1 September 1982
Ulrich Schwab, Harald Stein, Johannes Gerdes, Hilmar Lemke, Hartmut Kirchner, M. Schaadt
Citations873
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
Production of mouse monoclonal antibodies against the Hodgkin cell line L428 was described and one hybridoma antibody was found to be specific for H and SR cells of all Hodgkin's lymphomas tested and a minute, but distinct new cell population in normal tonsils and lymph nodes.
Abstract
The origins of the neoplastic cells in Hodgkin's lymphoma1, the Hodgkin (H) and Sternberg–Reed(SR) cells, are still obscure, and these cells appear to carry no markers found on any population of normal cells2,3. However the recent establishment of permanent Hodgkin cell lines3,4 has led to the search for tumour-specific antigens and/or for membrane markers on H and SR cells which may indicate the normal equivalent cells. Here, we describe the production of mouse monoclonal antibodies against the Hodgkin cell line L428. One hybridoma antibody, Ki-1, was found to be specific for H and SR cells of all Hodgkin's lymphomas tested and a minute, but distinct new cell population in normal tonsils and lymph nodes.
Keywords
Medicine
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