Improved survival in patients obtaining remission of nephrotic range albuminuria in diabetic nephropathy
Kidney InternationalPublished 11 August 2004Open access
Peter Hovind, Lise Tarnow, Peter Rossing, Bendix Carstensen, Hans‐Henrik Parving
Citations92
SJR quartileQ1
SJR score4.13
SNIP3.62
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TL;DR
It is suggested that remission of nephrotic range albuminuria in type 1 diabetic patients, induced by aggressive antihypertensive treatment with and without ACE inhibitors, is associated with a slower progression in diabetic nephropathy and a substantially improved survival.
Abstract
Our prospective study suggests that remission of nephrotic range albuminuria in type 1 diabetic patients, induced by aggressive antihypertensive treatment with and without ACE inhibitors, is associated with a slower progression in diabetic nephropathy and a substantially improved survival.
Keywords
Medicine
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BMJProteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus.
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BMJRenal protective effect of enalapril in diabetic nephropathy.
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The American Journal of MedicineMonitoring glomerular function in diabetic nephropathy
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JAMAThe Clinical Course of Diabetic Nephropathy
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