What is the probability of a chance prediction of a protein structure with an rmsd of 6 å?
Folding and DesignPublished 1 April 1998
Boris Reva, Alexei V. Finkelstein, Jeffrey Skolnick
Citations273
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TL;DR
The number of protein-like structures required to obtain a structure within an rmsd of 6 A to be 10(4)-10(5) for chains of 60-80 residues and 10(11-10(12) structures for chainsof 160-200 residues is estimated.
Abstract
We estimated the number of protein-like structures required to obtain a structure within an rmsd of 6 A to be 10(4)-10(5) for chains of 60-80 residues and 10(11)-10(12) structures for chains of 160-200 residues. The probability of obtaining a 6 A rmsd by chance is so remote that when such structures are obtained from a prediction algorithm, it should be considered quite successful.
Keywords
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