Characteristics of tryptophan accumulation by glial cells
Brain ResearchPublished 1 February 1974
Annie Bauman, S. Bourgoin, Philippe Benda, Jacques Glowinski, M. Hamon
Citations46
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
The data presented here suggest that tryptophan accumulation in glial cells could be dependent on allosteric changes of the carrier, which might be relevant to the understanding of 5-HT synthesis regulation.
Abstract
l-Tryptophan uptake was studied in C6 glial cells and found to be a very rapid and temperature dependent process. Kinetic analysis shows the presence of two saturable transport systems acting at different tryptophan concentrations. Both these high- and low-affinity processes were found in 3T3 fibroblast cultured cells, as well as in synaptosomes and cell suspensions obtained from rat cortex. No Na+ requirement could be demonstrated in a wide range of tryptophan concentrations. The data presented here suggest that tryptophan accumulation in glial cells could be dependent on allosteric changes of the carrier, which might be relevant to the understanding of 5-HT synthesis regulation.
Keywords
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