Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study
Biological PsychiatryPublished 12 January 2004
Gustav Schelling, Erich Kilger, Benno Roozendaal, Dominique J.‐F. de Quervain, Josef Briegel, Alexander Dagge
Citations345
SJR quartileQ1
SJR score4.68
SNIP2.24
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Stress doses of hydrocortisone in patients undergoing CS are associated with a lower intensity of chronic stress and PTSD symptoms at 6 months after CS.
Abstract
Stress doses of hydrocortisone in patients undergoing CS are associated with a lower intensity of chronic stress and PTSD symptoms at 6 months after CS.
Keywords
MedicineHealth Professions
New England Journal of MedicineProtective and Damaging Effects of Stress Mediators
6,564 Citations1998Bruce S. McEwen
The long-term effect of the physiologic response to stress is reviewed, which I refer to as allostatic load, which is the ability to achieve stability through change.
JAMAA new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
6,363 Citations1993J. R. Le Gall
The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis, and is a starting point for future evaluation of the efficiency of intensive care units.
JAMAA New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study
5,939 Citations1993Jean‐Roger Le Gall
The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis and is a starting point for future evaluation of the efficiency of intensive care units.
The LancetMortality by cause for eight regions of the world: Global Burden of Disease Study
4,064 Citations1997Christopher Murray, Alan D López
The Global Burden of Disease Study (GBD) used various data sources and made corrections for miscoding of important diseases (eg, ischaemic heart disease) to estimate worldwide and regional cause-of-death patterns in 1990, and the estimates by cause provide a foundation for a more informed debate on public-health priorities.
JAMAEffect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock
3,081 Citations2002Djillali Annane
NatureStress and glucocorticoids impair retrieval of long-term spatial memory
1,190 Citations1998Dominique J.‐F. de Quervain, Benno Roozendaal +1 more
It is shown that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when footshock is given 2’min or 4 h before testing, which suggests that the retention impairment is directly related to increased adrenocortical function.
New England Journal of MedicineCorticosteroid Insufficiency in Acutely Ill Patients
1,041 Citations2003Mark S. Cooper, Paul M. Stewart
The authors present an updated, practical approach to the diagnosis and treatment of hypoadrenalism in acutely ill patients, and summarizes the physiology of the corticosteroid response in acute illness.
Intensive Care MedicineEpidemiology of sepsis and infection in ICU patients from an international multicentre cohort study
979 Citations2001Corinne Alberti, Christian Brun‐Buisson +10 more
The crude incidence of ICU infections remains high, although the rate varies between ICUs and patient subsets, illustrating the added burden of nosocomial infections in the use ofICU resources.
Critical Care MedicineStress doses of hydrocortisone reverse hyperdynamic septic shock
896 Citations1999Josef Briegel, H. Forst +10 more
Infusion of stress doses of hydrocortisone reduced the time to cessation of vasopressor therapy in human septic shock and was associated with a trend to earlier resolution of sepsis-induced organ dysfunctions.
JAMAIncidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis
887 Citations1995C. Brun‐Buisson
Patients with clinically suspected sepsis but without microbiological documentation and patients with documented infection share common risk factors and are at similarly high risk of death.
Neurobiology of Learning and MemoryStress and Memory: Opposing Effects of Glucocorticoids on Memory Consolidation and Memory Retrieval,
828 Citations2002Benno Roozendaal
The hypothesis is proposed that these apparently dual effects of glucocorticoids on memory consolidation and memory retrieval might be related and that the basolateral complex of the amygdala is a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucOCorticoid effects on both memory consolidationand memory retrieval.
Current Opinion in NeurobiologyRole of adrenal stress hormones in forming lasting memories in the brain
818 Citations2002James L. McGaugh, Benno Roozendaal
Recent experiments investigating the effects of adrenal stress hormones on memory provide extensive evidence that epinephrine and glucocorticoids modulate long-term memory consolidation in animals and human subjects.
Critical Care MedicineMemory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care
773 Citations2001Christina Jones, Richard Griffiths +2 more
It is suggested that even relatively unpleasant memories for real events during critical illness may give some protection from anxiety and the later development of PTSD-related symptoms when memories of delusions are prominent.
JAMAIncidence, Risk Factors, and Outcome of Severe Sepsis and Septic Shock in Adults
764 Citations1995Christian Brun‐Buisson
Patients with clinically suspected sepsis but without microbiological documentation and patients with documented infection share common risk factors and are at similarly high risk of death.
PsychoneuroendocrinologyEnhanced memory for emotional material following stress-level cortisol treatment in humans
762 Citations2001Tony W. Buchanan, William R. Lovallo
It is suggested that high cortisol levels during arousing events result in enhanced memory in humans, and previous work on corticosteroid enhancement of memory is extended.
Critical Care MedicineSimplified Therapeutic Intervention Scoring System
674 Citations1996Dinis Reis Miranda, Angelique de Rijk +1 more
New England Journal of MedicineAspirin and Mortality from Coronary Bypass Surgery
670 Citations2002Dennis T. Mangano
Early use of aspirin after coronary bypass surgery is safe and is associated with a reduced risk of death and ischemic complications involving the heart, brain, kidneys, and gastrointestinal tract.
PsychoneuroendocrinologyGlucocorticoids and the regulation of memory consolidation
663 Citations2000Benno Roozendaal
Findings indicate that glucocorticoid effects on memory consolidation are mediated, in part, by an activation of GRs in the amygdala and that the effects require b-adrenergic activity in the BLA, which is in agreement with the general hypothesis that theBLA integrates hormonal and neuromodulatory influences onMemory consolidation.
Critical Care MedicineHealth-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome
593 Citations1998Gustav Schelling, Christian Stoll +12 more
Survivors of ARDS showed statistically significant impairments in all eight health dimensions of the SF-36 when compared with normal controls, and patients reporting multiple adverse experiences described the lowest health-related quality of life.
Psychiatric Clinics of North AmericaCurrent status of cortisol findings in post-traumatic stress disorder
510 Citations2002Rachel Yehuda
Findings of hypothalamic-pituitary-adrenal axis alterations in post-traumatic stress disorder are summarized and disparate findings are explained as illustrating a more complex neuroendocrinology of PTSD than has previously been described.
Neurobiology of Learning and MemoryEpinephrine enhancement of human memory consolidation: Interaction with arousal at encoding
455 Citations2003Larry Cahill, Michael T. Alkire
These findings support the view that endogenous stress hormones modulate memory consolidation for experiences that induce their release and suggest that in humans these hormones may interact with the degree of arousal at initial encoding of information to modulates memory consolidation processes for that information.
Clinical Psychology ReviewPosttraumatic stress disorder following medical illness and treatment
367 Citations2003Josephine E. Tedstone, Nicholas Tarrier
PTSD was described in studies investigating myocardial infarction, cardiac surgery, haemorrhage and stroke, childbirth, miscarriage, abortion and gynaecological procedures, intensive care treatment, human immunodeficiency virus (HIV) infection, awareness under anaesthesia, and in a group of miscellaneous conditions.
Biological PsychiatryInitial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims
344 Citations2000Douglas L. Delahanty, A. Jay Raimonde +1 more
It is suggested that initial cortisol levels in the immediate aftermath of a traumatic event contribute, in part, to subsequent symptoms of posttraumatic stress disorder.
European Journal of NeuroscienceGlucocorticoid‐induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe
342 Citations2003Dominique J.‐F. de Quervain, Katharina Henke +8 more
The present results provide further evidence that acutely elevated glucocorticoid levels can impair declarative memory retrieval processes and suggest that such impairments may be related to a disturbance of medial temporal lobe function.
Biological PsychiatryThe effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors
337 Citations2001Gustav Schelling, Josef Briegel +4 more
The administration of hydrocortisone during septic shock in a dosage similar to the endogenous maximal production rate was associated with a lower incidence of posttraumatic stress disorder in long-term survivors, which seems to be independent of the number of categories of traumatic memory.
PsychoneuroendocrinologySustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder
311 Citations1987Thomas R. Kosten, John Mason +3 more
It appears likely that the main underlying mechanisms for elevations of both hormones are psychological, but further work will be required to establish the exact nature of these mechanisms.
Intensive Care MedicineSensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment
283 Citations1999Christian Stoll, Hans‐Peter Kapfhammer +7 more
An existing questionnaire for diagnosis of PTSD was modified and validated and found to be a responsive, valid and reliable instrument to screen survivors of intensive care for PTSD.
Critical Care MedicineExposure to high stress in the intensive care unit may have negative effects on health-related quality-of-life outcomes after cardiac surgery
232 Citations2003Gustav Schelling, Markus Richter +7 more
Exposure to high stress in the cardiovascular intensive care unit can have negative effects onHRQL outcomes of cardiac surgery, and stress symptom scores were the most significant predictors of mental health HRQL outcomes.
NeuroImmunoModulationPlasma and Cerebrospinal Fluid Interleukin-6 Concentrations in Posttraumatic Stress Disorder
224 Citations2001Dewleen G. Baker, Nosa N. Ekhator +6 more
PTSD patients have increased CSF concentrations of IL-6 is not elevated but is more tightly associated with noradrenergic output in these patients than in normals, and both findings might be explained by the low cortisol secretion previously reported in PTSD.
Journal of Cardiothoracic and Vascular AnesthesiaThe inflammatory response to cardiopulmonary bypass
218 Citations1997Bruce E. Miller, Jerrold H. Levy
Certain types of clinical injury, such as severe trauma, burns, pancreatitis, and major surgery, can provoke such a profound response that it results in respiratory failure, coagulopathy, and multiorgan system dysfunction.
Critical Care MedicineThe effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors
200 Citations1999Gustav Schelling, Christian Stoll +6 more
Data from this study support the hypothesis that the administration of stress doses of hydrocortisone in doses equivalent to the maximal endocrine secretion rate during septic shock reduces the incidence of PTSD and improves emotional well-being in survivors.
Critical Care MedicineStress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery
185 Citations2003Erich Kilger, Florian Weis +9 more
Although the limitations of a nonblinded interventional trial are acknowledged, stress doses of hydrocortisone seem to attenuate systemic inflammation in a predefined risk group of patients after cardiac surgery with cardiopulmonary bypass and improve early outcome.
Journal of Thoracic and Cardiovascular SurgeryHealth-related quality of life and post-traumatic stress disorder in patients after cardiac surgery and intensive care treatment
184 Citations2000Christian Stoll, Gustav Schelling +8 more
Patients who have had cardiac surgery demonstrate a high life satisfaction with an acceptable degree of physical and mental health-related quality of life.
Acta Psychiatrica ScandinavicaTorture of a Norwegian ship's crew
125 Citations1989Lars Weisæth
During the summer of 1984, 14 seamen, the entire crew of a Norwegian ship, were seized upon arrival in Libya and subjected to psychological and physical torture because they were suspected of being enemies of the Libyan state.
Journal of the American Society of NephrologyImmunomodulation in Septic Shock
78 Citations2001Josef Briegel, MARGARETHE JOCHUM +2 more
Biochemical Society TransactionsGeneral Comparative and Clinical Endocrinology of the Adrenal Cortex
69 Citations1979N. Deshpande
Neurobiology of Learning and MemoryEffects of Stress Hormones on Traumatic Memory Formation and the Development of Posttraumatic Stress Disorder in Critically Ill Patients
61 Citations2002Gustav Schelling
The findings indicate that stress hormones influence the development of PTSD through complex and simultaneous interactions on memory formation and retrieval and that animal models of aversive learning are useful in analyzing and predicting clinical findings in critically ill humans.
Intensive Care MedicineThe ability of the Simplified Acute Physiology Score (SAPS II) to predict outcome in coronary care patients
58 Citations1997H.-P. Schuster, Frank Schuster +3 more
It is concluded that SAPS II is applicable to CCU patients in the authors' unit, and the probability of death in survivors and nonsurvivors was equally distributed in ICU and CCu patients.
Annals of the New York Academy of SciencesImplicit and Explicit Memory for Trauma‐Related Information in PTSD<sup>a</sup>
54 Citations1997Richard J. McNally
Experiments on content-dependent memory abnormalities in PTSD suggest that PTSD patients exhibit enhanced recall of words related to trauma relative to trauma-exposed persons with the disorder and directed forgetting research suggests that adult survivors of childhood sexual abuse who have PTSD exhibit memory deficits only for neutral and positive material.
Torture of a Norwegian Ship’s Crew
53 Citations1993Lars Weisæth
