MAP, an expert system for multiple pairwise linkage analysis
Annals of Human GeneticsPublished 1 July 1989
Newton E. Morton, Virginia Andrews
Citations53
SJR quartileQ3
SJR score0.51
SNIP0.50
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TL;DR
The logic of a program for multiple pairwise linkage analysis under interference is set forth, including a seriation algorithm to obtain a trial order, a mapping bootstrap to improve thetrial order, and three procedures for quality control to detect mistyping.
Abstract
The logic of a program for multiple pairwise linkage analysis under interference is set forth, including a seriation algorithm to obtain a trial order, a mapping bootstrap to improve the trial order, and three procedures for quality control to detect mistyping. This approach is compared with multipoint analysis under null interference, which substantially overestimates map length and cannot incorporate a variety of data.
Keywords
Biochemistry, Genetics and Molecular Biology
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