Longitudinal Evaluation of Prostate-Specific Antigen Levels in Men With and Without Prostate Disease
JAMAPublished 22 April 1992
H. Ballentine Carter
Citations1,075
SJR quartileQ1
SJR score5.35
SNIP10.71
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The most significant factor affecting serum PSA levels with age is the development of prostate disease, and rate of change in PSALevels may be a sensitive and specific early clinical marker for theDevelopment of prostate cancer.
Abstract
The most significant factor affecting serum PSA levels with age is the development of prostate disease. Rate of change in PSA levels may be a sensitive and specific early clinical marker for the development of prostate cancer.
Keywords
Medicine
The Journal of UrologyThe Development of Human Benign Prostatic Hyperplasia with Age
2,475 Citations1984Stephen J. Berry, Donald S. Coffey +2 more
The prevalence and growth rate of human benign prostatic hyperplasia with age is reported by combining and analyzing data from 10 independent studies containing more than 1,000 prostates.
New England Journal of MedicineProstate-Specific Antigen as a Serum Marker for Adenocarcinoma of the Prostate
2,471 Citations1987Thomas A. Stamey, Norman Yang +4 more
PSA is more sensitive than PAP in the detection of prostatic cancer and will probably be more useful in monitoring responses and recurrence after therapy, however, since both PSA and PAP may be elevated in benign prostatic hyperplasia, neither marker is specific.
New England Journal of MedicineMeasurement of Prostate-Specific Antigen in Serum as a Screening Test for Prostate Cancer
2,390 Citations1991William J. Catàlona, Deborah S. Smith +6 more
The combination of measurement of the serum PSA concentration and rectal examination, with ultrasonography performed in patients with abnormal findings, provides a better method of detecting prostate cancer thanrectal examination alone.
Journal of the American Statistical AssociationNewton—Raphson and EM Algorithms for Linear Mixed-Effects Models for Repeated-Measures Data
879 Citations1988Mary J. Lindstrom, Douglas M. Bates
The Journal of UrologyProstate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. II. Radical Prostatectomy Treated Patients
877 Citations1989Thomas A. Stamey, John N. Kabalin +5 more
No difference in preoperative or postoperative prostate specific antigen levels, cancer volume, seminal vesicle invasion or incidence of pelvic lymph node metastasis was seen, providing the first quantitative evidence that small amounts of capsular penetration may not be of biological or prognostic significance.
The Journal of UrologyPurification of a Human Prostate Specific Antigen
830 Citations2016M.C. Wang, Luis Valenzuela +2 more
This report presents the first demonstration of the purification of a prostate‐specific antigen that does not represent prostatic acid phosphatase and shows a single protein band on analytical polyacrylamide gel electrophoresis and isoelectric focusing.
The Journal of UrologyProstate Cancer Detection in a Clinical Urological Practice by Ultrasonography, Digital Rectal Examination and Prostate Specific Antigen
774 Citations1990William H. Cooner, B.R. Mosley +6 more
University Libraries (University of Maryland)Normal Human Aging: The Baltimore Longitudinal Study on Aging
765 Citations1984N. W. Shock, Richard C. Greulich +5 more
Normal Human Aging is an overview of the first 23 years of research findings about the natural course of human aging.
The Journal of UrologyProstate Specific Antigen in the Preoperative and Postoperative Evaluation of Localized Prostatic Cancer Treated with Radical Prostatectomy
585 Citations1988Joseph E. Oesterling, Daniel W. Chan +6 more
The Journal of UrologyClinical use of Prostate Specific Antigen in Patients with Prostate Cancer
510 Citations1989M’Liss A. Hudson, Robert R. Bahnson +1 more
It is concluded that the serum prostate specific antigen assay is most useful clinically to monitor the response to therapy of prostate cancer patients.
The Journal of UrologyProstate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. IV. Anti-Androgen Treated Patients
209 Citations1989Thomas A. Stamey, John N. Kabalin +2 more
Data suggest that serum prostate specific antigen determination 6 months after introduction of therapy is capable of distinguishing patients with a favorable and persisting response to anti-androgen therapy from those in whom a limited response can be expected.
The ProstateCumulative prevalence of prostatism matches the autopsy prevalence of benign prostatic hyperplasia
202 Citations1990H. A. Guess, H. Michael Arrighi +2 more
The proportion of the male population with clinically recognizable prostatism by a given age is about the same as the proportion with pathological evidence of BPH, according to a compilation of five independent autopsy studies involving 1,075 prostates.
The Journal of UrologyThe Influence of Reversible Androgen Deprivation on Serum Prostate-Specific Antigen Levels in Men with Benign Prostatic Hyperplasia
132 Citations1989Jed P. Weber, Joseph E. Oesterling +4 more
It is demonstrated that serum prostate-specific antigen is related to prostatic size, prostatic epithelial weight, and testosterone stimulation, and there is tremendous variation in the relative amount of epithelium in a prostate.
The ProstateSymptoms and signs of prostatism as risk factors for prostatectomy
111 Citations1990H. Michael Arrighi, Harry A. Guess +2 more
This is the first study to document the extent to which urologic symptoms and a digital rectal examination predict subsequent prostatectomy for BPH.
The Journal of UrologyProliferative Activity of Benign Human Prostate, Prostatic Adenocarcinoma and Seminal Vesicle Evaluated by Thymidine Labeling
69 Citations1982John S. Meyer, Gerald Sufrin +1 more
The data support participation of both epithelial and stromal proliferation in nodular hyperplasia, and indicate a low basal proliferative rate in normal prostatic glands.