Obesity-induced inflammatory changes in adipose tissue
Journal of Clinical InvestigationPublished 15 December 2003Open access
Kathryn E. Wellen, Gökhan S. Hotamışlıgil
Citations1,768
SJR quartileQ1
SJR score4.72
SNIP2.17
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
This issue of the JCI reports that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue.
Abstract
Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.
Keywords
Medicine
PubMedMutation of the mouse klotho gene leads to a syndrome resembling ageing.
66,549 Citations1997Sneha Banerjee, Yanchun Zhao +14 more
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Journal of Clinical InvestigationObesity is associated with macrophage accumulation in adipose tissue
8,556 Citations2003Stuart P. Weisberg, Daniel McCann +4 more
Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
Journal of Clinical InvestigationObesity is associated with macrophage accumulation in adipose tissue
8,280 Citations2003Stuart P. Weisberg, Daniel McCann +4 more
ScienceAdipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
7,453 Citations1993Gökhan S. Hotamışlıgil, Narinder S. Shargill +1 more
A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal of Clinical InvestigationChronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
5,833 Citations2003Haiyan Xu, Glenn T. Barnes +9 more
It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
Journal of Clinical InvestigationChronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
5,610 Citations2003Haiyan Xu, Glenn T. Barnes +9 more
NatureA central role for JNK in obesity and insulin resistance
3,336 Citations2002Jiro Hirosumi, Gürol Tuncman +6 more
It is shown that JNK activity is abnormally elevated in obesity and an absence of JNK1 results in decreased adiposity, significantly improved insulin sensitivity and enhanced insulin receptor signalling capacity in two different models of mouse obesity.
Hormone Research in PaediatricsDifferential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents
3,057 Citations2013Hae Jin Kim, Sun Young Park +4 more
It is suggested that the relationship between plasma visfatin concentrations and metabolic parameters differs according to central adiposity and that plasma visFatin concentrations are correlated with visceral fat and triglyceride levels, especially in children and adolescents with lower adiposity.
NatureProtection from obesity-induced insulin resistance in mice lacking TNF-α function
2,230 Citations1997K. Teoman Uysal, Sarah M. Wiesbrock +2 more
Results indicate that TNF-alpha is an important mediator of insulin resistance in obesity through its effects on several important sites of insulin action.
Nature MedicineDiet-induced insulin resistance in mice lacking adiponectin/ACRP30
2,083 Citations2002Norikazu Maeda, Iichiro Shimomura +18 more
The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
ScienceReversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>
1,867 Citations2001Minsheng Yuan, Nicky Konstantopoulos +5 more
It is shown that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling and identifies the IKKβ pathway as a target for insulin sensitization.
CellPPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL
1,809 Citations1998Peter Tontonoz, László Nagy +3 more
It is demonstrated that the nuclear receptor PPARγ is induced in human monocytes following exposure to oxLDL and is expressed at high levels in the foam cells of atherosclerotic lesions, and it is suggested that endogenous PParγ ligands may be important regulators of gene expression during atherogenesis.
ScienceBiological Action of Leptin as an Angiogenic Factor
1,373 Citations1998M. Rocı́o Sierra-Honigmann, Anjali K. Nath +9 more
It is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells, indicating that the vascular endothelium is a target for leptin and suggesting a physiological mechanism whereby leptin-induced angiogenesis may facilitate increased energy expenditure.
Nature MedicineLack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
685 Citations2001Liza Makowski, Jeffrey B. Boord +9 more
Through its distinct actions in adipocytes and macrophages, aP2 provides a link between features of the metabolic syndrome and could be a new therapeutic target for the prevention of atherosclerosis.
ScienceFunction of GATA Transcription Factors in Preadipocyte-Adipocyte Transition
541 Citations2000Qiang Tong, Gökhan Dalgin +4 more
It is shown that murine GATA-2 and Gata-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation.
Nature MedicineTargeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
538 Citations2001Mylène Perreault, André Marette
It is shown that iNOS expression is increased in muscle and fat of genetic and dietary models of obesity and mice in which the gene encodingiNOS was disrupted are protected from high-fat–induced insulin resistance.
Genes & DevelopmentLeptin-specific patterns of gene expression in white adipose tissue
527 Citations2000Alexander A. Soukas, Paul Cohen +2 more
expression monitoring of 6500 genes using oligonucleotide microarrays in wild-type, ob/ob, and transgenic mice expressing low levels of leptin revealed that differences in ambient leptin levels have dramatic effects on the phenotype of white adipose tissue.
Journal of Biological ChemistryPreadipocyte Conversion to Macrophage
508 Citations2003Guillaume M. Charrière, Béatrice Cousin +5 more
The results suggest that preadipocytes have the potential to be very efficiently and rapidly converted into macrophages and reinforces the link between adipose tissue and innate immunity processes.
EndocrinologyComprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor γ Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive Tissues
344 Citations2001James M. Way, W. Wallace Harrington +7 more
The effects of the potent, tyrosine-based PPARγ ligand GW1929 on serum glucose and lipid parameters and gene expression in Zucker diabetic fatty rats are characterized and a comprehensive and unbiased messenger RNA profiling technique is used to identify genes regulated either directly or indirectly by PParγ in epididymal white adipose tissue, interscapular brown adipose tissues, liver, and soleus skeletal muscle.
ScienceAdipsin and Complement Factor D Activity: An Immune-Related Defect in Obesity
314 Citations1989Barry S. Rosen, Kathleen Sue Cook +6 more
It is suggested that adipsin and the alternative pathway of complement may play an unexpected but important role in the regulation of systemic energy balance in vivo.