HLA Class II genes associated with REM sleep behavior disorder

Annals of NeurologyPublished 1 February 1996

Carlos H. Schenck, Edgar García‐Rill, Miriam Segall, Harriet Noreen, Mark W. Mahowald

DOI10.1002/ana.410390216

Source URL

Citations89

SJR quartileQ1

SJR score3.74

SNIP2.26

TL;DR

Another disorder of REM sleep dysregulation (besides narcolepsy) appears to be strongly associated with specific HLA class I1 genes.

Abstract

Twenty-five white men with rapid eye movements (REM) sleep behavior disorder, but without narcolepsy, underwent HLA class II antigen typing: 84% (N=21) were DQwl (DQB1*05,06) positive (28% [N=7] were DR2 positive); DQB1*0501 (N=9) and DQB1*0602 (N=7) were the most common phenotypes. The 84% DQwl rate in men with REM sleep behavior disorder was significantly greater (p=0.015) than the 56% DQwl rate found in a local white comparison group (N=66), and was greater than the 39 to 66% DQwl rates published for 12 white groups (N=40-418/group). Thus, another disorder of REM sleep dysregulation (besides narcolepsy) appears to be strongly associated with specific HLA class II genes.

Keywords

PsychologyNeuroscience

Journal of Psychosomatic ResearchPrinciples and practice of sleep medicine

1,397 Citations1995Eileen P. Sloan

Annals of Internal MedicineThe Effects of Coffee and Napping on Nighttime Highway Driving

651 Citations2006Pierre Philip, Jacques Taillard +5 more

A controlled, crossover study of real driving at night and the effects of coffee or napping on nighttime driving performances in a real-life environment showed that sleepiness and performances are significantly more affected by sleep deprivation in a simulated environment than in the real world.

Electroencephalography and Clinical NeurophysiologyExcessive daytime sleepiness in man: Multiple sleep latency measurement in narcoleptic and control subjects

458 Citations1978Gary S. Richardson, Mary A. Carskadon +4 more

It is concluded that the Multiple Sleep latency test, in addition to providing opportunities to clinically document sleep onset REM sleep periods, can demonstrate pathological sleepiness.

Journal of Sleep ResearchREM sleep behaviour disorder: an update on a series of 96 patients and a review of the world literature

325 Citations1993Carlos H. Schenck, Thomas D. Hurwitz +1 more

RBD in humans is a complex syndrome in which there is generalized REM and NREM sleep motor dyscontrol, as was originally observed in the animal RBD model by Jouvet and Delorme in 1965.

View PDF

JAMARapid Eye Movement Sleep Behavior Disorder

313 Citations1987Carlos H. Schenck

The RBD was unrelated to psychopathologic conditions but in five cases was closely linked with major neuropathologic disorders: dementia, olivopontocerebellar degeneration, subarachnoid hemorrhage, and the Guillain-Barre syndrome.

Annals of NeurologyMotor dyscontrol in narcolepsy: Rapid‐eye‐movement (REM) sleep without atonia and REM sleep behavior disorder

305 Citations1992Carlos H. Schenck, Mark W. Mahowald

It is reported that another previously described abnormality of REM sleep, REM sleep behavior disorder, may also be a symptom of narcolepsy, and 17 patients diagnosed by established criteria for nar colepsy and for REMSleep behavior disorder most commonly emerged in tandem.

Journal of Sleep ResearchMotor dyscontrol in sleep of narcoleptic patients (a lifelong development?)

75 Citations1993Geert Mayer, K. Meier‐Ewert

In this retrospective study 27 narcoleptic patients were divided into two groups and Polygraphic and videometry data, medical history, medication, blood chemistry, psychological and neuroradiological data of the two groups of patients were compared.

Progress in NeurobiologyThe neurobiology of narcolepsy-cataplexy

59 Citations1993Michael S. Aldrich

View PDF

Narcolepsy and HLA in the Federal Republic of Germany: Population and Family Data

8 Citations1988K. Meier‐Ewert, G. Mueller‐Eckhardt +1 more

Fifty-nine unrelated narcolepsy patients as well as 14 families, including 16 patients and 44 healthy relatives, were investigated for MHC class I, class II, and class III alleles, and Glyoxalase-1 was determined as an additional marker in family studies.

HLA in Narcolepsy in France

1 Citations1988Michel Billiard, J Seignalet +7 more

The genetic aspect of narcolepsy in man has long been considered, with a number of series published suggesting either an autosomal dominant mode of inheritance with incomplete penetrance or a two-threshold multifactorial system.