Carvedilol Inhibits Reactive Oxygen Species Generation by Leukocytes and Oxidative Damage to Amino Acids
CirculationPublished 18 January 2000Open access
Paresh Dandona, Rajaram Karne, Husam Ghanim, Wael Hamouda, Ahmad Aljada, Cesar H. Magsino
Citations141
SJR quartileQ1
SJR score8.67
SNIP8.30
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TL;DR
It is concluded that carvedilol significantly inhibits ROS generation by leukocytes and oxidative conversion of phenylalanine to m- and o-tyrosine and antioxidant effect in humans in vivo.
Abstract
BACKGROUND: The purpose of this study was to test whether carvedilol has an antioxidant effect in humans in vivo. METHODS AND RESULTS: We administered 3.125 mg of carvedilol twice daily to normal subjects for 1 week. ROS generation by polymorphonuclear leukocytes and mononuclear cells fell from 314+/-183.43 and 303+/-116 mV to 185+/-157 and 189+/-63 mV (P<0.025), respectively. m-Tyrosine fell from 4.24+/-0.99 to 4.03+/-0.97 ng/mL (P=0.01), and o-tyrosine fell from 4.59+/-1.10 to 4.24+/-0.99 ng/mL (P=0.004) in the absence of a change in phenylalanine concentrations. CONCLUSIONS: We conclude that carvedilol significantly inhibits ROS generation by leukocytes and oxidative conversion of phenylalanine to m- and o-tyrosine.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
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