Literature-curated protein interaction datasets

An evaluation of existing curation of protein interaction experiments reported in the literature found that curation can be error-prone and possibly of lower quality than commonly assumed.

Abstract

High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.