The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus
Brain ResearchPublished 1 July 1990
Ian D. Hentall, V. Budhrani
Citations10
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
It is argued that both effects of IPN stimulation and single-cell activity in the nucleus raphe magnus of rats under pentobarbital anesthesia are hyperalgetic.
Abstract
The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cells (92%) were found to be inhibited by IPN stimulation, whereas on-cells (50%) were excited. Based on previously suggested roles for the NRM neurons, we argue that both effects are hyperalgetic.
Keywords
MedicineNeuroscience
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