Severe exacerbations and BODE index: Two independent risk factors for death in male COPD patients
Respiratory MedicinePublished 8 January 2009
Juan José Soler‐Cataluña, Miguel Ángel Martínez‐García, Lourdes Sánchez Sánchez, Miguel Perpiñá Tordera, Pilar Román Sánchez
Citations311
SJR quartileQ1
SJR score1.06
SNIP1.02
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Severe exacerbations of COPD imply an increased mortality risk that is independent of baseline severity of the disease as measured by the BODE index, but on replacing exacerbation with exercise capacity the multidimensional grading system is simplified without loss of predictive capacity.
Abstract
Severe exacerbations of COPD imply an increased mortality risk that is independent of baseline severity of the disease as measured by the BODE index. The combined application of both parameters (e-BODE index) didn't improve the predictive capacity, but on replacing exacerbation with exercise capacity the multidimensional grading system is simplified without loss of predictive capacity.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Journal of Chronic DiseasesA new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
49,938 Citations1987Mary E. Charlson, Peter Pompei +2 more
The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death fromComorbid disease for use in longitudinal studies and further work in larger populations is still required to refine the approach.
Springer series in statisticsNonparametric Estimation from Incomplete Observations
45,533 Citations1992Edward L. Kaplan, Paul Meier
Journal of the Royal Statistical Society Series B (Statistical Methodology)Regression Models and Life-Tables
39,259 Citations1972D. R. Cox
Journal of the American Statistical AssociationNonparametric Estimation from Incomplete Observations
39,052 Citations1958Edward L. Kaplan, Paul Meier
American Journal of Respiratory and Critical Care MedicineGlobal Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
16,096 Citations2012Jørgen Vestbo, Suzanne S. Hurd +11 more
It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
RadiologyA method of comparing the areas under receiver operating characteristic curves derived from the same cases.
7,050 Citations1983J A Hanley, Barbara J. McNeil
This paper refines the statistical comparison of the areas under two ROC curves derived from the same set of patients by taking into account the correlation between the areas that is induced by the paired nature of the data.
American Journal of Respiratory and Critical Care MedicineGlobal Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
4,686 Citations2007Klaus F. Rabe, Suzanne S. Hurd +9 more
The GOLD initiative will continue to bring COPD to the attention of governments, public health officials, health care workers, and the general public, but a concerted effort by all involved in health care will be necessary.
The LancetMortality by cause for eight regions of the world: Global Burden of Disease Study
4,064 Citations1997Christopher Murray, Alan D López
The Global Burden of Disease Study (GBD) used various data sources and made corrections for miscoding of important diseases (eg, ischaemic heart disease) to estimate worldwide and regional cause-of-death patterns in 1990, and the estimates by cause provide a foundation for a more informed debate on public-health priorities.
New England Journal of MedicineThe Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease
4,043 Citations2004Bartolomé R. Celli, Claudia Côté +6 more
The BODE index, a simple multidimensional grading system, is better than the FEV1 at predicting the risk of death from any cause and from respiratory causes among patients with COPD.
ThoraxSevere acute exacerbations and mortality in patients with chronic obstructive pulmonary disease
1,922 Citations2005Juan José Soler‐Cataluña
JAMAEffects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study
1,579 Citations1994Nicholas R. Anthonisen
JAMAEffects of Smoking Intervention and the Use of an Inhaled Anticholinergic Bronchodilator on the Rate of Decline of FEV1
1,314 Citations1994Nicholas R. Anthonisen
An aggressive smoking intervention program significantly reduces the age-related decline in FEV 1 in middle-aged smokers with mild airways obstruction and use of an inhaled anticholinergic bronchodilator results in a relatively small improvement inFEV 1 that appears to be reversed after the drug is discontinued.
Annals of Internal MedicineThe Effects of a Smoking Cessation Intervention on 14.5-Year Mortality
1,223 Citations2005Nicholas R. Anthonisen, M.A. Skeans +4 more
The smoking cessation program was associated with cumulative reduced decline in lung function (FEV1) that was largest in participants who stopped smoking early in the study; inhaled ipratropium produced a small noncumulative increase in FEV1 that disappeared when the drug was withdrawn.
CHEST JournalToward a Consensus Definition for COPD Exacerbations
964 Citations2000Roberto Rodríguez-Roisin
This paper summarizes the discussions of the workshop, "COPD: Working Towards a Greater Understanding," in which the participants proposed the following working definition of an exacerbation of COPD: a sustained worsening of the patient's condition that is acute in onset and necessitates a change in regular medication in a patient with underlying COPD.
American Review of Respiratory DiseasePrognosis in Chronic Obstructive Pulmonary Disease
786 Citations1986N. R. Anthonisen, E C Wright +2 more
Patients with low initial values of FEV1 showed relatively little further decline, probably indicating a survivor effect, and mortality in the present series was less than that of a previous series, and the same as that of hypoxemic patients with COPD who received continuous home O2 therapy.
ThoraxLung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study
653 Citations2003David M. Mannino
The presence of both obstructive and restrictive lung disease is a significant predictor of earlier death in long term follow up in a national cohort of US adults both with and without lung disease.
American Journal of Respiratory and Critical Care MedicineInspiratory-to-Total Lung Capacity Ratio Predicts Mortality in Patients with Chronic Obstructive Pulmonary Disease
596 Citations2005Ciro Casanova, Claudia Côté +5 more
The power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease was analyzed and it was found to be a good and independent predictor of all-cause and respiratory mortality.
PubMedSpirometric reference values from a Mediterranean population.
502 Citations1986Josep Roca, J. Sanchís +6 more
To the authors' knowledge, this study provides reliable spirometric equations from a large urban Mediterranean sample which were lacking so far in the literature.
European Respiratory JournalPulmonary rehabilitation and the BODE index in COPD
340 Citations2005Claudia Côté, B. R. Celli
Pulmonary rehabilitation participation improves BODE and is associated with better outcomes, and the BODE index change after pulmonary rehabilitation provides valuable prognostic information.
CHEST JournalA Multidimensional Grading System (BODE Index) as Predictor of Hospitalization for COPD
255 Citations2005Kian-Chung Ong, Arul Earnest +1 more
The BODE staging system, which includes in addition to FEV1 other physiologic and clinical variables, helps to better predict hospitalization for COPD.
CHEST JournalImpact of COPD Exacerbations on Patient-Centered Outcomes
253 Citations2007Claudia Côté, L. J. Dordelly +1 more
The BODE index is a sensitive tool used to assess the impact of exacerbations and to monitor COPD disease progression and there was little change in Bode index score at 2 years in nonexacerbators.
American Review of Respiratory DiseaseComparison of Clinical Dyspnea Ratings and Psychophysical Measurements of Respiratory Sensation in Obstructive Airway Disease
231 Citations1987Donald A. Mahler, Richard Rosiello +4 more
Comparisons indicate that in patients with symptomatic OAD, clinical methods for rating dyspnea are interrelated and are correlated with lung function, but are independent of perception of resistive breathing loads.
Respiratory MedicinePrediction of risk of COPD exacerbations by the BODE index
152 Citations2008José M. Marı́n, Santiago Carrizo +5 more
The BODE index is a better predictor of the number and severity of exacerbations in COPD than FEV(1) alone.
Respiratory Medicine COPD UpdateSevere acute exacerbations and mortality in patients with chronic obstructive pulmonary disease
126 Citations2006Juan José Soler‐Cataluña, Miguel Ángel Martínez‐García +4 more
Birkhäuser Boston eBooksDiscrimination Index, the Area Under the ROC Curve
40 Citations2002Byung‐Ho Nam, Ralph B. D’Agostino