The Effect of Diamphenethide on Fasciola hepatica at Different Stages of Development

Research in Veterinary SciencePublished 1 July 1973

S.B. Kendall, J.W. Parfitt

DOI10.1016/s0034-5288(18)33849-9

Source URL

Citations19

SJR quartileQ1

SJR score0.61

SNIP0.81

TL;DR

Diamphenethide given orally at 100 mg/kg was tested against Fasciola hepatica of various ages in sheep experimentally infected each with 600 metacercariae and there was a correlation between size and maturity as shown by the state of development of the sexual organs.

Abstract

Diamphenethide given orally at 100 mg/kg was tested against Fasciola hepatica of various ages in sheep experimentally infected each with 600 metacercariae. The efficacy was 100% against 1-week-old flukes, 99% at 3, 5 and 7 weeks and 83% and 85% at 9 and 11 weeks respectively. In infections over 1 week old there was great variability in the sizes of the parasites in each animal. Up to 9 weeks of age there was a correlation between size and maturity as shown by the state of development of the sexual organs so that no conclusion could be reached as to whether size per se or the state of maturity was critical in determining the response to diamphenethide.

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