Genomic imprinting and genetic disorders in man
Trends in GeneticsPublished 1 January 1989
Wolf Reik
Citations173
SJR quartileQ1
SJR score3.93
SNIP2.86
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TL;DR
It is suggested that genomic imprinting, an epigenetic process that marks maternal and paternal chromosomes in mammals, is involved in parental effects of genetic disorders in mammals.
Abstract
In a considerable number of genetic disorders in the human, the phenotypic expression of the disease can depend on maternal or paternal inheritance of the mutation. It is suggested that genomic imprinting, an epigenetic process that marks maternal and paternal chromosomes in mammals, is involved in such parental effects.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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