Malignant neuroleptic syndrome: An atypical case

PsychosomaticsPublished 1 December 1979

Richard A. Bernstein

Citations48

Abstract

Mary Simmerson Cunningham Logan (Mrs. John A. Logan) thanks President Roosevelt for his effort to secure a position for General Black.

Keywords

Medicine

Canadian Journal of Anesthesia/Journal canadien d anesthésieMalignant hyperthermia: A statistical review

410 Citations1970Beverley A. Britt, W. Kalow

The finding that males were somewhat more commonly affected than were females in patients who responded to general anaesthetics with malignant hyperthermia does not contradict previous observations of dominant inheritance of the syndrome.

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JAMALithium Carbonate, Haloperidol, and Irreversible Brain Damage

393 Citations1974Wendy J. Cohen

Four acutely agitated patients with diagnoses of mania were treated with a combined regimen of lithium carbonate and high doses of haloperidol—a form of therapy that had been used previously in Metropolitan Hospital without reported adverse effects; in these four, severe encephalopathic syndromes developed.

Psychiatric Clinics of North AmericaDrug-Induced Extrapyramidal Syndromes

131 Citations2016Stanley N. Caroff, E. Cabrina Campbell

A better understanding of drug-induced effects on the motor circuit may improve patient safety, enhance antipsychotics effectiveness, and provide insights into mechanisms underlying antipsychotic activity in parallel brain circuits.

PsychopharmacologyRigidity, hyperpyrexia and coma following fluphenazine enanthate

108 Citations1973Herbert Y. Meltzer

Beginning one day after receiving fluphenazine enanthate, 25 mg, subcutaneously, an acute schizophrenic girl with mixed schizoaffective and excited catatonic symptomatology became mute and withdrawn, then developed severe muscular rigidity and hyperpyrexia, and finally became comatose.

Utrecht University Repository (Utrecht University)Drug-induced extrapyramidal syndromes

101 Citations2002Igor Schillevoort

The aim of this thesis is to quantify the risk of drug-induced EPS for drugs commonly associated with this side effect and to quantify the influence of specific risk factors.

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Psychiatry and Clinical NeurosciencesMalignant Neuroleptic Syndrome—Its Present Status in Japan and Clinical Problems

100 Citations1977Hitoshi Itoh, Nobuo Ohtsuka +4 more

Fourteen cases in which hyperpyrexia, akinesia, mutism, extrapyramidal symptoms and severe, diverse autonomic symptoms developed in the course of neuroleptic drug therapy are reported as the malignant neuroleptic syndrome are reported.

International review of neurobiologyDrugs and Body Temperature

92 Citations1970Peter Lomax

In this chapter, attention is directed mainly to agents for which there is evidence indicating a direct action on the thermoregulatory centers in the central nervous system.

Williams & Wilkins eBooksPsychotropic drug side effects : clinical and theoretical perspectives

79 Citations1970Richard I. Shader, Alberto DiMascio

American Journal of PsychiatryHeat Stroke in Phenothiazine-Treated Patients: A Report of Three Fatalities

64 Citations1970Samuel Zelman, Ramon A. Guillan

The authors stress the need for lower phenothiazine dosages where possible, limited use of supplemental anticholinergic agents, and awareness of the susceptibility of phenothsiazine-treated patients to the hazards of extreme temperatures.

PubMedFatal hyperthermia following haloperidol therapy of sedative-hypnotic withdrawal.

47 Citations1978Greenblatt Dj, Gross Pl +3 more

The sequence of events strongly suggests that haloperidol therapy was casually related to the development of fatal hyperthermia, and the butyrophenone haloperodol, like the phenothiazine derivatives, can produce clinically important impairment of thermoregulation.