Development of cold-adapted recombinant live, attenuated influenza A vaccines in the U.S.A. and U.S.S.R.
Antiviral ResearchPublished 1 February 1982Open access
Alan P. Kendal, H. F. Maassab, G. I. Alexandrova, Yuri Ghendon
Citations79
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TL;DR
The ability to recombine influenza viruses by mixed infections during which the segmented RNA genome can reassort raised the prospect that once a suitable attenuated vaccine strain of influenza A was prepared, this property could be transferred to a new strain with contemporary HA and NA antigens.
Abstract
ts is used to designate viruses exhibiting >10 s loglo reduction in infectious titer at non-permissive temperatures of >38°C compared to titer at permissive temperature of 33-34°C.
Keywords
Immunology and MicrobiologyMedicine
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