Modest Weight Gain and the Development of Diabetes: Another Perspective

The risk for diabetes with even modest typical adult weight gain is substantial, and the importance of maintaining a constant body weight throughout adult life is stressed, which differs from the 1990 U.S. Department of Agriculture guidelines, which imply that substantial weight gain at age 35 years and a body mass index as high as 27 kg/m2 are healthy.

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Editorials1 April 1995Modest Weight Gain and the Development of Diabetes: Another PerspectiveJames R. Sowers, MDJames R. Sowers, MDWayne State University, Detroit, MI 48201Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-7-199504010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Significant obesity is associated with metabolic abnormalities that are considered to be risk factors for cardiovascular disease, including impaired glucose tolerance and non-insulin-dependent diabetes mellitus, hypertension, and an abnormal lipoprotein profile [1-3]. The National Institutes of Health Consensus Development Panel [4] concluded in 1985 that “the evidence is now overwhelming that obesity, defined as excessive storage of energy in the form of fat, has adverse effects on health and longevity.” If obesity is defined as a body mass index of 20% above the desirable index (roughly a body mass index of 27 kg/m2), approximately 34 million adult Americans can be ...References1. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, et al. Hyperinsulinemia. A link between hypertension obesity and glucose intolerance. J Clin Invest. 1985; 75:809-17. Google Scholar2. Stevens J, Keil JE, Rust PF, Verdugo RR, Davis CE, Tyroler HA, et al. Body mass index and body girths as predictors of mortality in black and white women. Arch Intern Med. 1992; 152:1257-62. Google Scholar3. Despres JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. 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Hyperinsulinemia as a possible etiology for the high prevalence of non-insulin dependent diabetes in Mexican Americans. Diabetes Metab. 1987; 13:337-44. Google Scholar Author, Article, and Disclosure InformationAuthors: James R. Sowers, MDAffiliations: Wayne State University, Detroit, MI 48201Corresponding Author: James R. Sowers, MD, Division of Endocrinology and Hypertension, Wayne State University School of Medicine, UHC-4H, 4201 St. Antoine, Detroit, MI 48201. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWeight Gain as a Risk Factor for Clinical Diabetes Mellitus in Women Graham A. Colditz , Walter C. Willett , Andrea Rotnitzky , and JoAnn E. Manson Metrics Cited byANTIHYPERTENSIVE PHARMACOTHERAPY IN HYPERTENSIVE PATIENTS AT A TERTIARY CARE TEACHING HOSPITAL AND MEDICAL COLLEGE IN INDIAContinuous Glucose Monitoring in Patients Undergoing Cardiac SurgeryPregnancy: a “teachable moment” for weight control and obesity preventionObesity in Middle and Older AgeTreatment of cardiac risk factors in diabetic patients: How well do we follow the guidelines?Obesity, hypertension, and vascular diseaseObesity and cardiovascular diseaseTherapeutic challenges in the obese diabetic patient with hypertensionDiabetes Mellitus and Hypertension, Emerging Therapeutic Perspectives 1 April 1995Volume 122, Issue 7Page: 548-549KeywordsAdipose tissueBody mass indexFatsInsulinInsulin resistanceLongitudinal studiesObesityOverweightType 2 diabetesWeight gain ePublished: 15 August 2000 Issue Published: 1 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...