Cognitive functioning in Chronic Fatigue Syndrome and the role of depression, anxiety, and fatigue
Journal of Psychosomatic ResearchPublished 1 June 2002
Keryn Short, Marita P. McCabe, Greg Tooley
Citations64
SJR quartileQ1
SJR score1.31
SNIP1.10
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
CFS sufferers did not demonstrate any impairment in objective cognitive functioning compared to the control group, and objective performance was not related to their higher levels of depression or their level of fatigue.
Abstract
The results are discussed in terms of the heterogeneity of the CFS population and the complex interaction of symptomatological factors that characterise CFS.
Keywords
MedicineHealth Professions
Clinical Psychology ReviewPsychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
11,814 Citations1988Aaron T. Beck, Robert A. Steer +1 more
British Journal of Social and Clinical PsychologyDevelopment of a Rating Scale for Primary Depressive Illness
8,470 Citations1967Max Hamilton
This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Annals of Internal MedicineThe Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
5,018 Citations1994Keiji Fukuda, Stephen E. Straus +5 more
This work proposes a conceptual framework and a set of guidelines that provide a comprehensive, systematic, and integrated approach to the evaluation, classification, and study of persons with this condition and other fatiguing illnesses.
Journal of Neurology Neurosurgery & PsychiatryNeuropsychological assessment.
3,266 Citations1995Lisa Cipolotti, E. K. Warrington
C cognitive neuropsychologists have succeeded in showing many dissociations between the subcomponents of cognitive skills that allow valid conclusions about the nature and functions of the impaired processing components to be drawn.
Perceptual and Motor SkillsPaced Auditory Serial-Addition Task: A Measure of Recovery from Concussion
2,386 Citations1977Dorothy Gronwall
The paced auditory serial-addition test, a measure of rate of information processing, is presented as a convenient test for estimating individual performance during recovery and procedures for administration and control data are given.
Archives of Clinical NeuropsychologyWechsler memory scale-revised
2,113 Citations1988C. R. Reynolds, Jeffrey Powel
Annals of Internal MedicineChronic Fatigue Syndrome: A Working Case Definition
1,722 Citations1988Gary P. Holmes, JONATHAN E. KAPLAN +14 more
A new name is proposed for the chronic Epstein-Barr virus syndrome--the chronic fatigue syndrome--that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue.
Journal of Psychosomatic ResearchDimensional assessment of chronic fatigue syndrome
1,301 Citations1994Jan H. Vercoulen, C.M.A. Swanink +4 more
The absence of laboratory tests and clear criteria to identify homogeneous (sub)groups in patients presenting with unexplained fatigue, and to assess clinical status and disability in these patients, calls for further assessment methods.
Journal of Psychosomatic ResearchThe measurement of fatigue: A new instrument
540 Citations1993Joseph E. Schwartz, Lina Jandorf +1 more
A 29-item fatigue assessment instrument is presented, its psychometric properties are described, and it is used to differentiate normal fatigue from fatigue related medical disorders.
Journal of Clinical and Experimental NeuropsychologyA preliminary profile of neuropsychological deficits associated with major depression
508 Citations1997Hans O. F. Veiel
Both the severity and the profile of cognitive deficiencies in depression are postulated to be similar to those seen in moderately severe traumatic brain injury.
Annals of Internal MedicineChronic Fatigue Syndrome Research
290 Citations1992Ann Schluederberg, Stephen E. Straus +6 more
A workshop to address critical issues in research concerning the chronic fatigue syndrome (CFS) was held at the National Institutes of Health on 18 to 19 March 1991.
Journal of Neurology Neurosurgery & PsychiatryCognitive behaviour therapy in chronic fatigue syndrome.
276 Citations1991S Butler, Trudie Chalder +2 more
Cognitive behaviour therapy led to substantial improvements in overall disability, fatigue, somatic and psychiatric symptoms and suggested that advice currently offered to chronic patients, to avoid physical and mental activity, is counterproductive.
The British Journal of PsychiatryThe Psychiatric Status of Patients with the Chronic Fatigue Syndrome
262 Citations1990Ian B. Hickie, Andrew R. Lloyd +2 more
The pattern of psychiatric symptoms in the CFS patients was significantly different to that of 48 patients with non-endogenous depression, but was comparable with that observed in other medical disorders.
Journal of Neurology Neurosurgery & PsychiatryPrognosis in chronic fatigue syndrome: a prospective study on the natural course.
215 Citations1996Jan H. Vercoulen, C.M.A. Swanink +4 more
The improvement rate in patients with a relatively long duration of complaints is small and psychological factors are related to improvement, especially cognitive factors.
Archives of NeurologyInformation Processing Efficiency in Chronic Fatigue Syndrome and Multiple Sclerosis
199 Citations1993John DeLuca, Susan K. Johnson +1 more
The cognitive performance of subjects with chronic fatigue syndrome, multiple sclerosis, and healthy controls was compared for age, education, and verbal intelligence as previous neuropsychological studies of CFS had not used appropriate control groups.
Journal of Neurology Neurosurgery & PsychiatryNeuropsychological impairments in chronic fatigue syndrome, multiple sclerosis, and depression.
159 Citations1995John DeLuca, Susan K. Johnson +2 more
The chronic fatigue syndrome group did not differ from the depressed group in overall neuropsychological performance, but differed from the multiple sclerosis and control groups, and the most significant impairment was in information processing speed in the chronic fatigue Syndrome group.
Journal of Psychosomatic ResearchAttributions and self-esteem in depression and chronic fatigue syndromes
144 Citations1990Richard Powell, Raymond J. Dolan +1 more
It is suggested that an outward style of attribution protects the depressed CFS patients from cognitive changes associated with low mood but at the expense of greater vulnerability towards somatic symptoms such as fatigue.
Psychological MedicineCan the chronic fatigue syndrome be defined by distinct clinical features?
140 Citations1995Ian B. Hickie, Andrew R. Lloyd +4 more
Clinical heterogeneity among patients currently diagnosed as CFS is demonstrated, suggesting aetiological heterogeneity, in the absence of discriminative clinical features, current consensus criteria do not necessarily reduce the heterogeneity of patients recruited to CFS research studies.
Journal of Neurology Neurosurgery & PsychiatryCognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease.
139 Citations1997John DeLuca, Susan K. Johnson +2 more
Impaired cognition in chronic fatigue syndrome cannot be explained solely by the presence of a psychiatric condition.
Journal of Clinical and Experimental NeuropsychologyNeuropsychology of chronic fatigue syndrome: A critical review
131 Citations1997Lana A. Tiersky, Susan K. Johnson +3 more
The most consistently documented neuropsychological impairments are in the areas of complex information processing speed and efficiency, and general intellectual abilities and higher order cognitive skills are intact.
Journal of Neurology Neurosurgery & PsychiatryMemory, attention, and executive function in chronic fatigue syndrome.
121 Citations1996Eileen M. Joyce, Stephen Blumenthal +1 more
Patients with chronic fatigue syndrome have reduced attentional capacity resulting in impaired performance on effortful tasks requiring planned or self ordered generation of responses from memory.
Journal of Affective DisordersDepression in fatiguing illness: comparing patients with chronic fatigue syndrome, multiple sclerosis and depression
117 Citations1996Sverre Urnes Johnson
Analysis of symptoms as a percentage of total BDI score revealed no significant differences in mood or vegetative items among the three groups, but the CFS and MS groups exhibited a significantly lower percentage of self-reproach symptoms than DEP, whereas the DEP group showed a higher percentage of somatic symptoms.
Journal of Neurology Neurosurgery & PsychiatryAnalysis of neuropsychological functioning in patients with chronic fatigue syndrome.
111 Citations1993Jordan Grafman, V Schwartz +4 more
The results on objective testing indicated that CFS patients had some mild memory impairment, but only on tasks requiring conceptually driven encoding and retrieval processes.
Psychosomatic MedicineCognitive Slowing and Working Memory Difficulties in Chronic Fatigue Syndrome
97 Citations1997Paul Marshall, Michele Forstot +3 more
It is concluded that, although CFS and major depression and dysthymia have distinct clinical features, these disorders have slowed motor and cognitive processing speed in common.
British Journal of Clinical PsychologyQuality of attention in chronic fatigue syndrome: Subjective reports of everyday attention and cognitive difficulty, and performance on tasks of focused attention
88 Citations1993Colette Ray, Lin Phillips +1 more
Evidence of psychomotor retardation is found, with patients having longer response times for word reading and colour naming in the Stroop test, and Difficulties in interpreting findings for both subjective and objective cognitive measures are discussed.
The British Journal of PsychiatryCognitive Functioning and Magnetic Resonance Imaging in Chronic Fatigue
87 Citations1995H Cope, Amanda Pernet +2 more
Subjective complaints of cognitive impairment are a prominent feature of chronic fatigue, but objective cognitive and MRI abnormalities are not, probably reflecting psychopathology rather than a post-viral process.
Journal of Clinical and Experimental NeuropsychologyEvaluating Neuropsychological Impairment in Chronic Fatigue Syndrome
78 Citations1998J H Vercoulen, Ellen Bazelmans +5 more
Journal of Neurology Neurosurgery & PsychiatryEffects of exercise on cognitive and motor function in chronic fatigue syndrome and depression
77 Citations1998Susan Kim Blackwood, S. M. MacHale +3 more
Patients with chronic fatigue syndrome show a specific sensitivity to the effects of exertion on effortful cognitive functioning, suggesting that patients have reduced working memory capacity, or a greater demand to monitor cognitive processes, or both.
NeurologyAttention and short‐term memory in chronic fatigue syndrome patients
75 Citations1992Marten K. Scheffers, R H Johnson +3 more
The ERP and performance data from both paradigms suggest that perceptual, attentional, and short-term memory processes were unaffected in CFS patients and that the differences were limited to response-related processes.
Acta Psychiatrica ScandinavicaGeneralized anxiety disorder in chronic fatigue syndrome
71 Citations1997Benjamin Fischler, Raymond Cluydts +3 more
The American Journal of MedicineInfluence of exhaustive treadmill exercise on cognitive functioning in chronic fatigue syndrome
70 Citations1998John J. LaManca, Sue Ann Sisto +6 more
It is concluded that after physically demanding exercise, CFS subjects demonstrated impaired cognitive processing compared with healthy individuals.
Australian Journal of PsychologyThe effects of anxiety on verbal and spatial task performance
67 Citations1991Roslyn Markham, Shane Darke
Psychological MedicineCognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS)
66 Citations1997Alison Wearden, Louis Appleby
Novartis Foundation symposiumClinical Presentation of Chronic Fatigue Syndrome
64 Citations2007Anthony L. Komaroff
The symptomatology suggesting an organic component to the illness includes its abrupt onset with an 'infectious-like' illness, intermittent unexplained fevers, arthralgias and 'gelling' (stiffness).
Journal of Psychosomatic ResearchResearch on cognitive complaints and cognitive functioning in patients with chronic fatigue syndrome (CFS): What conclusions can we draw?
64 Citations1996Alison Wearden, Louis Appleby
The inconsistency between cognitive complaints and results of tests of cognitive functioning resembles that found in other subject groups and may be due in part to the inappropriate use of laboratory memory tests for assessing "everyday" cognitive functioning.
The British Journal of PsychiatryCognitive deficits in patients suffering from chronic fatigue syndrome, acute infective illness or depression
63 Citations1997Uté Vollmer‐Conna, Denis Wakefield +5 more
The differences in severity of mood disturbance suggest that the pathophysiological processes in patients with CFS and acute infection are not simply secondary to depressed mood, as all patients demonstrated similar deficits in attention and response speed.
Biological PsychiatryCognitive deficits in patients with chronic fatigue syndrome
61 Citations1996Barbara Marcel, Anthony L. Komaroff +3 more
It is suggested that at least a subset of CFS patients may experience significant impairments in learning and memory.
Psychological MedicineThe difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness
59 Citations2000S. M. LAWRIE, Siobhán MacHale +3 more
Diurnal changes in some functions inMDD may differentiate the disorder from CFS, and patients with CFS show similarly substantial motor impairment, but cognitive deficits are generally more marked in MDD.
Psychological MedicineEDITORIAL Is the chronic fatigue syndrome best understood as a primary disturbance of the sense of effort?
56 Citations1997Stephen M. Lawrie, Siobhán MacHale +2 more
Controversy has raged as to its aetiology, particularly the relative importance of viruses and other infectious agents, the contribution of neuromuscular abnormalities and whether the association with psychiatric disorders is primary or secondary.
Biological PsychiatryAn assessment of cognitive function and mood in chronic fatigue syndrome
50 Citations1996Paul Marshall, David Watson +5 more
The CFS patients' ability to attend to verbal versus figural stimuli and mood ratings were different from those reported in studies of patients with depression and encourage further assessment of cognitive dysfunction and mood in CFS.
Journal of Clinical and Experimental NeuropsychologyCognitive Functioning in Patients with Chronic Fatigue Syndrome
50 Citations1996Véronique Michiels, Raymond Cluydts +4 more
Two neuropsychological variables indicating aspects of psychomotor performance and verbal memory were found to discriminate best between patients and controls.
Personality and Individual DifferencesPASAT: Observed correlations with IQ
50 Citations1988Vincent Egan
Clinical Infectious DiseasesCognitive Functioning of Patients with Chronic Fatigue Syndrome
44 Citations1994Susan K. Johnson, John DeLuca +2 more
Results of the studies discussed in this paper suggest that impaired information processing, rather than primary memory dysfunction, may be at the root of the cognitive problems that afflict so many patients with CFS.
Perceptual and Motor SkillsSelective Impairment of Auditory Processing in Chronic Fatigue Syndrome: A Comparison with Multiple Sclerosis and Healthy Controls
37 Citations1996Susan K. Johnson, John DeLuca +2 more
The present study examined subjects with Chronic Fatigue Syndrome, multiple sclerosis, and healthy controls on an auditory-versus visual-paced serial-addition test to examine the possibility of a modality-specific impairment.
PubMedNeuropsychological and psychological functioning in chronic fatigue syndrome.
34 Citations1997Kane Rl, Gantz Nm +1 more
The results support previous findings of notable levels of psychological distress among chronic fatigue syndrome patients and suggest the need for alternative research paradigms to assess the cognitive abilities of CFS patients.
Chronic fatigue syndrome
29 Citations2012Michael Sharpe, Simon Wessely
Toxicology and Industrial HealthNeuropsychiatric Status of Patients with Chronic Fatigue Syndrome: An Overview
18 Citations1994John DeLuca, Susan K. Johnson +1 more
The hypothesis of the neuropsychological impairments in CFS is discussed and studies from the laboratory contrasting CFS with patients with multiple sclerosis, depression, and healthy controls are detailed.
Neuropsychology ReviewNeurocognitive functioning in chronic fatigue syndrome
17 Citations1996Raymond K. DiPino, Robert L Kane
The current paper reviews studies that have examined the neurocognitive and/or psychological functioning of individuals with CFS and suggests changes in research design and instruments employed to study individuals withCFS are suggested.