ATP Prevents both Hydroperoxide‐Induced Hydrolysis of Pyridine Nucleotides and Release of Calcium in Rat Liver Mitochondria
European Journal of BiochemistryPublished 1 July 1981Open access
T. J. Mühlebach, Hans‐Ruedi LÖTSCHER, Kaspar H. Winterhalter, Christoph Richter, Willy Hofstetter
Citations76
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TL;DR
It is proposed that a compound deriving from NAD(P)+ is an important factor in the calcium release mechanism in rat liver mitochondria.
Abstract
The mechanism of the hydroperoxide-induced release of calcium from rat liver mitochondria was investigated. In calcium-loaded mitochondria both the hydroperoxide-induced hydrolysis of pyridine nucleotides and the release of calcium is inhibited by intramitochondrial ATP. In submitochondrial particles, in the absence of ATP a hydrolytic product of NAD+, probably ADP-ribose, binds covalently to a protein of the inner mitochondrial membrane. It is proposed that a compound deriving from NAD(P)+ is an important factor in the calcium release mechanism in rat liver mitochondria.
Keywords
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