Neurohypophysial peptides in the gonads: are they real and do they have a function?
Reproduction Fertility and DevelopmentPublished 1 June 1990
B. T. Pickering, V. J. Ayad, Sonia D. Birkett, Colin Gilbert, S. E. F. Guldenaar, HD Nicholson
Citations21
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SJR score0.33
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TL;DR
The vasopressin-like peptides that also occur in the gonads are focused on and the reader is directed to work on such peptides by reference at the appropriate places, and further consideration can be found in the reviews by Clements and Funder and Wathes.
Abstract
Reproduction, Fertility and Development is an international journal publishing original research , review and comment in the fields of reproduction and developmental biology in humans, domestic animals and wildlife
Keywords
MedicineNeuroscience
NatureGonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism
572 Citations1977B.M. Cattanach, CAROL A. IDDON +3 more
The genetic and endocrinological background of a mutant strain of mouse in which the testes and ovaries fail to develop postnatally is reported, which should prove useful for studying the synthesis of hypothalamic releasing hormones as well as the role of the hypothalamic–gonadotrophin system in sexual differentiation, puberty, folliculogenesis and spermatogenesis.
NatureX-linked Gene for Testicular Feminization in the Mouse
553 Citations1970Mary F. Lyon, S Hawkes
There is no evidence at present that the gene for testicular feminization is involved in mouse spermatogenesis, at least up to the sPermatocyte stage.
American Journal of AnatomyThe wave of the seminiferous epithelium in the rat
337 Citations1961Bernard Perey, Y. Clermont +1 more
Animal Reproduction ScienceHormone receptor control of pulsatile secretion of PGF2α from the ovine uterus during luteolysis and its abrogation in early pregnancy
271 Citations1984John A. McCracken, Willfried Schramm +1 more
A hypothesis is presented to explain the hormone receptor control of episodic pulsatile secretion of PGF2α in the cyclic sheep, including a possible mechanism for its abrogation during early pregnancy.
NatureIs oxytocin an ovarian hormone?
266 Citations1982D.C. Wathes, R. W. Swann
The discovery of large amounts of oxytocin within the ovine corpus luteum reported here may provide an explanation of why there may exist different controls of reflex release and basal secretion of Oxytocin.
ReproductionPulsatile secretion of gonadotrophins, ovarian steroids and ovarian oxytocin during the periovulatory phase of the oestrous cycle in the cow
245 Citations1984D. L. Walters, E. Schallenberger
It is concluded that the frequent, high-amplitude pulses of oestradiol that occur before and during the LH surge are probably due to stimulation by pulses of LH, and very little, if any, oxytocin is secreted from the ovary during the periovulatory phase of the oestrous cycle.
EndocrinologyOxytocin-Stimulated Release of Prostaglandin F<sub>2α</sub>from Ovine Endometrium<i>in Vitro</i>: Correlation with Estrous Cycle and Oxytocin-Receptor Binding1<sup>1</sup>
238 Citations1976J.S. Roberts, John A. McCracken +2 more
NatureOvarian secretion of oxytocin is stimulated by prostaglandin
231 Citations1982A. P. F. Flint, E. L. Sheldrick
It is shown that in sheep, the concentration of oxytocin in ovarian venous blood exceeds that in arterial blood, and it is found that ovarian secretion of Oxytocin is stimulated by a prostaglandin F2α analogue.
Journal of Dairy ScienceAlteration of the Bovine Estrous Cycle with Oxytocin
223 Citations1959David T. Armstrong, William Hansel
Oxytocin was less effective in causing diestrual shortening when either atropine or reserpine was administered concurrently, and was completely ineffective in inducing precocious estrus in hysterectomized, but not in sham-operated, heifers.
ReproductionEvidence for a systemic role for ovarian oxytocin in luteal regression in sheep
206 Citations1983A. P. F. Flint, E. L. Sheldrick
The data are consistent with a role for ovarian secretion of oxytocin in response to uterine release of PGF-2 alpha in the control of luteal regression and more frequent sampling revealed that two thirds of detected surges of uterine secretion of prostaglandin (PG) F-2alpha were accompanied by raised levels of Oxytocin.
Cell and Tissue ResearchSelective destruction and regeneration of rat Leydig cells in vivo
195 Citations1985J. B. Kerr, K. Donachie +1 more
EDS offers a valuable opportunity to study further the interactions between the seminiferous tubules and the interstitial tissue following the destruction and subsequent regeneration of the Leydig cells, suggesting that an interstitial precursor cell, as yet unidentified, gives rise to a new Leydigs cell population.
Journal of EndocrinologyEndocrine control of uterine oxytocin receptors in the ewe
179 Citations1985E. L. Sheldrick, A. P. F. Flint
It is concluded that the oxytocin receptor is present in both components of the endometrium, as well as in the myometrium and that changes in uterine receptor concentrations before oestrus are consistent with receptor activation by steroid hormones.
Endocrine ReviewsMechanisms Controlling Corpus Luteum Function in Sheep, Cows, Nonhuman Primates, and Women Especially in Relation to the Time of Luteolysis
163 Citations1988Frederick J. Auletta, A. P. F. Flint
By determining the function of luteal steroidogenic cells at different stages during the life of the CL it may be possible to identify factors causing luteolysis and those required for the maintenance of pregnancy.
The EMBO JournalThe gene for the hypothalamic peptide hormone oxytocin is highly expressed in the bovine corpus luteum: biosynthesis, structure and sequence analysis.
160 Citations1984Richard Ivell, D. Richter
It is reported here that at least the oxytocin gene is highly transcribed in the bovine corpus luteum during the mid‐luteal phase of the oestrous cycle.
Regulatory PeptidesIdentification of oxytocin and vasopressin in the testis and in adrenal tissue
153 Citations1984Helen Nicholson, R. W. Swann +4 more
The concentrations of the hormone were too great to be explained by known circulating levels of the polypeptides, and their presence in steroid secreting organs suggests a possible role for them in steroidogenesis.
ReproductionDelayed luteal regression in ewes immunized against oxytocin
145 Citations1980E. L. Sheldrick, Murray D. Mitchell +1 more
This finding supports the hypothesis that the luteolytic action of oestradiol-17 beta in sheep may be mediated through a stimulatory effect on the endometrial oxytocin receptor concentration.
Clinics in Endocrinology and Metabolism10 Paracrine control of the testis
145 Citations1986Richard M. Sharpe
It is argued that advances in knowledge of the paracrine control of the testis should have major repercussions on the authors' ability to understand, and eventually treat, idiopathic infertility in men, and also to induce infertility for contraceptive purposes.
EndocrinologyCharacterization of Oxytocin, Vasopressin, and Neurophysin from the Bovine Corpus Luteum*
141 Citations1983D.C. Wathes, R. W. Swann +3 more
The results show that the bovine ovary is a rich source of neurohypophysial peptides and suggest that oxytocin biosynthesis may occur within the corpus luteum.
Biochemical JournalStimulation of phosphoinositide hydrolysis by oxytocin and the mechanism by which oxytocin controls prostaglandin synthesis in the ovine endometrium
140 Citations1986A. P. F. Flint, W. M. F. Leat +2 more
It is proposed that the stimulation of endometrial prostaglandin synthesis by oxytocin is accounted for by increased hydrolysis of phosphoinositides to diacylglycerol and inositol phosphates with subsequent release of arachidonic acid from diacydonic acid.
ReproductionComparative protective actions of gonadotrophins and testosterone against the antispermatogenic action of ethane dimethanesulphonate
136 Citations1984C. M. Jackson, Helen C. Jackson
Although histological protection of spermatogenesis appeared complete with testosterone or hCG, effects on fertility remained but over different periods of time, and it is suggested that EDS binds to Leydig cells irreversibly, interfering with the action of gonadotrophin.
FEBS LettersOvulation triggers oxytocin gene expression in the bovine ovary
128 Citations1985Richard Ivell, Kevin H. Brackett +2 more
Oxytocin Neurophysin Corpus luteum Estrous cycle Gene expression Oxytocin-related signaling pathways are regulated by EMT, leading to EMT-dependent cell reprograming and down-regulation in the female immune system.
EndocrinologyThe Effects of Daily Administration of Single and Multiple Injections of Gonadotropin-Releasing Hormone on Pituitary and Gonadal Function in the Hypogonadal (<i>hpg</i>) Mouse*
112 Citations1983H. M. Charlton, DMG Halpin +12 more
In male hpg mice, single daily sc injections of GnRH at dosages from 50 ng to 20 μg for 20 days increased the pituitary FSH content from about 500 ng to 17,800–32,200 ng/pituitary, the content in normal mice being about 20,000 ng/ Pituitary.
EndocrinologyHUMAN PLACENTAL AND BOVINE CORPORA LUTEAL OXYTOCIN
110 Citations1983Phillip A. Fields, RUBY K. ELDRIDGE +3 more
Extracts of human placental and pregnant bovine luteal tissues contained immunoreactive oxytocin (“contractin factor”) which inhibited the in vitro mouse uterus responsiveness to the relaxation normally observed upon addition of relaxin (RXN).
NatureDirect inhibition of testicular androgen biosynthesis revealing antigonadal activity of neurohypophysial hormones
110 Citations1981Eli Y. Adashi, Aaron J.W. Hsueh
It is reported that arginine-vasotocin as well as other naturally occurring neurohypophysial hormones can act independently of the hypothalamic–pituitary unit to exert a direct inhibition of testicular androgen biosynthesis in vitro.
Biological Chemistry Hoppe-SeylerThe Neurohypophyseal Hormones Vasopressin and Oxytocin. Precursor Structure, Synthesis and Regulation
105 Citations1986Monika Rehbein, Mären Hillers +5 more
The LancetNEUROHYPOPHYSIAL HORMONES IN THE HUMAN OVARY
103 Citations1982D.C. Wathes, B. T. Pickering +4 more
The yields of both hormones were too great to be explained by known circulating levels in non-pregnant women, and suggests that these hormones are either taken up by the ovary from a neurohypophysial source or else manufactured locally, and they may therefore have a previously unsuspected role in the control of ovarian activity.
ReproductionREVIEW Possible actions of gonadal oxytocin and vasopressin
93 Citations1984D.C. Wathes
The subject merits reconsideration and in compiling this review it is hoped that a reappraisal of the earlier data from a new viewpoint might help to suggest what functions these gonadal hormones could be having.
European Journal of EndocrinologyDynamics of oxytocin, estrogen and progestin receptors in the bovine endometrium during the estrous cycle
87 Citations1988Heinrich H.D. Meyer, Th. Mittermeier +1 more
The data indicate that owing to an increasing sensitivity of the endometrium to progesterone and estradiol after day 12, these steroids may be mainly responsible for the initiation of first PGF2 alpha surges and luteolysis.
EndocrinologyLARGE LUTEAL CELLS THE SOURCE OF LUTEAL OXYTOCIN IN THE SHEEP
87 Citations1983Raymond J. Rodgers, J.D. O’SHEA +3 more
The large luteal cells are the source of the oxytocin produced by the cyclical corpus luteum of the sheep, and enriched fractions of enzymatically dispersed small and large lutesal cells from 12 CL were prepared.
Journal of Dairy ScienceLuteal Inhibition in the Bovine as a Result of Oxytocin Injections, Uterine Dilatation, and Intrauterine Infusions of Seminal and Preputial Fluids
87 Citations1960William Hansel, W. C. Wagner
The results suggest that the uterus plays an important role in regulating estrous cycle length and luteal development in the bovine.
The Journal of Clinical Endocrinology & MetabolismPresence of Oxytocin and Arginine Vasopressin in Human Ovary, Oviduct, and Follicular Fluid*
85 Citations1984James M. Schaeffer, James Liu +2 more
The results demonstrate the presence of high concentrations of oxytocin and AVP in human ovarian and oviductal tissues as well as follicular fluid and suggest that neurohypophyseal peptides have a paracrine role in the regulation of ovarian or ovidUCTal functions.
EndocrinologyIdentification and Characterization of Arginine Vasopressin Receptors in the Rat Testis*
82 Citations1985Rina Meidan, Aaron J.W. Hsueh
The presence of high affinity, stereospecific receptors for AVP in the interstitial cell compartment of the rat testis is demonstrated and suggested that the testis may contain the V1 receptor subtype.
NatureImmunoreactive arginine-vasopressin in Brattleboro rat ovary
82 Citations1984Alan T. Lim, Stephen J. Lolait +7 more
The detection and localization of immunoreactive (ir) AVP in the luteal cells of adult homozygous Brattleboro rats, and the modulation of this ovarian ir-AVP by gonadotropins are reported.
ReproductionOvarian oxytocin and the maternal recognition of pregnancy
79 Citations1986A. P. F. Flint, E. L. Sheldrick
In pregnancy corpus luteum function is maintained, and secretion of oxytocin, or its actions on the uterus, appear to be inconsistent with the successful establishment of gestation.
Journal of EndocrinologyOxytocin may play a role in the control of the human corpus luteum
77 Citations1982G. J. S. Tan, R. Tweedale +1 more
Evidence is provided for an effect of oxytocin on the human corpus luteum and increased secretion of this hormone may be important in the demise of the corpus lutenum at the end of the menstrual cycle.
ReproductionVariations in oxytocin, vasopressin and neurophysin concentrations in the bovine ovary during the oestrous cycle and pregnancy
72 Citations1984D.C. Wathes, R. W. Swann +1 more
The concentrations of both peptide hormones were maximal during the first half of the cycle and declined before those of progesterone, which suggests that oxytocin is synthesized locally.
Proceedings of the Royal Society of London Series B Containing Papers of a Biological CharacterThe action of animal extracts on milk secretion
72 Citations1911E. A. Schafer, Kenneth Mackenzie
It cannot be contested that the secretion of milk is influenced through the nervous system, but this may be indirect, if the formation and outpouring of the secretion can be shown to be produced by chemical agents (hormones) circulating in the blood.
FEBS LettersBiosynthesis of oxytocin in the corpus luteum
69 Citations1984R. W. Swann, Peter J. O’Shaughnessy +4 more
The Journal of Clinical Endocrinology & MetabolismHuman Ovaries Contain Immunoreactive Oxytocin*
68 Citations1983Firyal S. Khan‐Dawood, M. Yusoff Dawood
Findings indicate the presence of immunoreactive OT in human ovaries, with significant concentrations in the corpus luteum and preovulatory follicles, it is probable that these tissues produce OTs or an OT-like material which may function as an ovarian luteolytic agent.
International Journal of AndrologyAssessment of the role of Leydig cell products other than testosterone in spermatogenesis and fertility in adult rats
66 Citations1988Richard M. Sharpe, Hamish M. Fraser +1 more
The results suggest that Leydig cell products other than testosterone are not essential for maintenance of spermatogenesis and fertility in rats, although because of increased germ cell degeneration during the final stages of meiosis, a small reduction in sperm count may occur.
Journal of Biological ChemistryIdentification and characterization of arginine vasopressin-like substances in the rat testis.
65 Citations1985Barry G. Kasson, Rina Meidan +1 more
The supernatant of homogenized, acid-extracted rat testes was found to contain AVP immunoreactivity which showed parallelism with synthetic AVP in a specific radioimmunoassay for AVP, and these results suggest a paracrine or autocrine role of the neurohypophysial hormone at the testis level.
Cell and Tissue ResearchImmunocytochemical evidence for the presence of oxytocin in rat testis
64 Citations1985S. E. F. Guldenaar, B. T. Pickering
The presence of immunoreactive oxytocin was demonstrated in 80% of the interstitial cell population of both rat strains while no staining was observed for vasopressin or neurophysin.
Endocrine ReviewsArginine Vasopressin (AVP) and AVP-Like Immunoreactivity in Peripheral Tissues
64 Citations1986Judith A. Clements, John W. Funder
Recently, the presence of many neuropeptides, including AVP, has been demonstrated in a number of peripheral, mainly endocrine tissues, largely on immunochemical criteria.
ReproductionEffects of oxytocin on the bovine corpus luteum of early pregnancy
63 Citations1982G. J. S. Tan, R. Tweedale +1 more
Evidence is provided for an effect of oxytocin on the bovine corpus luteum of early pregnancy and the response of the luteal cells to hCG and may be inhibitory to basal progesterone production.
Cell and Tissue ResearchImmunocytochemical evidence for the presence of oxytocin and neurophysin in the large cells of the bovine corpus luteum
63 Citations1984S. E. F. Guldenaar, D.C. Wathes +1 more
The simultaneous presence of immunoreactive oxytocin and immunore Active Oxytocin-neurophysin was demonstrated in large luteal cells of non-pregnant animals, while no staining for vasopressin or vasopressing peptides was observed.
EndocrinologyEvidence For Relaxin in Corpora Lutea of Late Pregnant Cows*
62 Citations1980Michael J. Fields, Phillip A. Fields +2 more
Electrofocusing of the 6000 molecular weight fraction demonstrated three fractions which were capable of inhibiting contractions of the mouse uterus and which cross-reacted with porcine relaxin antiserum, and the isoelectric points of these three fractions were 8.8, 10.1, and 11.5.
ReproductionA combined radioimmunoassay and immunocytochemical study of ovarian oxytocin production during the periovulatory period in the ewe
61 Citations1986D.C. Wathes, S. E. F. Guldenaar +4 more
Corpora lutea and follicles were taken from the ovaries of 12 ewes at intervals from the start of luteolysis until 3 days after ovulation and immunocytochemical picture suggested that neurophysin immunoreactivity increased within a few hours of ovulation but that processing to oxytocin may be delayed.
Journal of EndocrinologyComparison of the effects on purified Leydig cells of four hormones (oxytocin, vasopressin, opiates and LHRH) with suggested paracrine roles in the testis
59 Citations1987Richard M. Sharpe, Irene Cooper
An LHRH agonist (LHRH-A) exerted clear-cut effects on testosterone secretion by Leydig cells both in vitro and in vivo, and vasopressin exerted effects in vitro which were similar to those of LHRh-A.
Endocrine ReviewsArginine Vasopressin in the Testis: An Intragonadal Peptide Control System*
58 Citations1986Barry G. Kasson, Eli Y. Adashi +1 more
All the known naturally occurring neurohypophysial hormones of vertebrates are endowed with a disulfide bridge and display phylogenetic constancy for amino acids at positions 1, 5, 6, 7, and 9; however, substitutions have occurred in the remaining amino acids thereby modifying biological activity and potency.
Cell and Tissue ResearchUltrastructural localisation of oxytocin and neurophysin in the ovine corpus luteum
57 Citations1986D.T. Theodosis, F. B. P. Wooding +2 more
Oxytocin and neurophysin seem to be rapidly lost after secretion since exocytosed granule cores showed no labelling above background levels.
TheriogenologyOxytocin-induced oestrus in the goat
56 Citations1981R.G. Cooke, A. Knifton
Subcutaneous administration of oxytocin between days 3-6, inclusive, significantly reduced the length of the oestrous cycle in goats and completely prevented the effect of the prostaglandin synthetase inhibitor, meclofenamic acid.
ReproductionContinuous infusion of oxytocin prevents induction of uterine oxytocin receptor and blocks luteal regression in cyclic ewes
55 Citations1985A. P. F. Flint, E. L. Sheldrick
Since cloprostenol, a PGF-2 alpha analogue, overcame the antiluteolytic action of oxytocin, it is suggested that continuous Oxytocin treatment may inhibit uterine production of PGF -2 alpha, possibly by down regulating the uterine oxytoc in receptor.
ReproductionDo small and large luteal cells of the sheep interact in the production of progesterone?
53 Citations1985R.J. Rodgers, J. D. O'Shea +1 more
It was concluded that the inhibitory action of PGF-2 alpha on LH-stimulated progesterone production may require the interaction of large and small luteal cells, but that oxytocin is not likely to be an intermediary in this interaction.
European Journal of EndocrinologyThe effect of active and passive immunization against oxytocin on ovarian cyclicity in ewes
52 Citations1983D. Schams, S. Prokopp +1 more
Active and passive immunization of ewes against oxytocin prolonged the luteal phase of the oestrous cycle, as evaluated by oestrus behaviour and determination of progesterone.
Journal of EndocrinologyCatecholamines and ascorbic acid as stimulators of bovine ovarian oxytocin secretion
50 Citations1987Martín Luck, B. Jungclas
It is concluded that catecholamines may be involved in the regulation of ovarian oxytocin secretion, that ascorbate may regulate oxytoc in secretion through its involvement in the biosynthesis of Oxytocin but also through interaction with catechlamines and, thirdly, that the stimulatory action of theca tissue probably does not involve the action of beta-agonists.
European Journal of EndocrinologyOxytocin determination in steroid producing tissues and in vitro production in ovarian follicles
50 Citations1985D. Schams, Th.A.M. Kruip +1 more
Production increased during lute inization indicating that luteinization is an important step for the production of oxytocin in ovaries, and de novo synthesis was indicated.
Experimental Biology and MedicineThe galactagogue action of the thymus and corpus luteum
47 Citations1910Isaac Ott, James C. Scott
In experiments upon the goat with the glands containing internal secretions, the corpus luteum, pineal body and thymus increased the quantity of milk fourfold in five minutes, and infundibulin is still the most powerful galactagogue, increasing the secretion of milk one-hundredfold.
ReproductionCOMPARATIVE EFFECTS OF METHYLENE, ETHYLENE AND PROPYLENE DIMETHANESULPHONATES ON THE MALE RAT REPRODUCTIVE SYSTEM
44 Citations1970E. R. A. Cooper, Helen C. Jackson
FEBS LettersDemonstration of mRNAs for oxytocin and prolactin in porcine granulosa and luteal cells
44 Citations1986Ralf Einspainer, L. Pitzel +5 more
The likelihood of a paracrine function of oxytocin and prolactin in the porcine ovary was inferred from the invitro effects of both both hormones on progesterone secretion of ovarian cells.
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43 Citations1911Kenneth Mackenzie
It is concluded that there are no nerves in the mammary gland, supported by the fact that neither section of the nerve trunks supplied to this gland nor their faradic stimulation appears to have any influence on the secretion of milk.
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39 Citations1985R.G. Cooke, A.M. Homeida
The major effect of immunization would appear to be suppression of the synthesis of the uterine luteolysin PGF-2 alpha, thus confirming that endogenous oxytocin has a facilitatory role inLuteolysis via prostaglandin production.
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39 Citations1985M. C. Richardson, G. M. C. Masson
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ReproductionOxytocin infusion from Day 10 after oestrus extends the luteal phase in non-pregnant cattle
36 Citations1989Colin Gilbert, G. E. Lamming +3 more
It is concluded that continuous administration of oxytocin can extend the luteal life-span in cattle.
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34 Citations1988J.J. Knickerbocker, H. R. Sawyer +3 more
It was concluded further that the epididymis of the ram does not synthesize oxytocin, but about 22 ng/day enters the epidIDymis in rete testis fluid, and it is more likely that the luminal Oxytocin influences epithelial or sperm function.
Journal of EndocrinologyEthan-1,2-dimethanesulphonate reduces testicular oxytocin content and seminiferous tubule movements in the rat
34 Citations1987HD Nicholson, R. T. S. Worley +2 more
The drug ethan-1,2-dimethanesulphonate is used to suggest that the Leydig cells are the main source of oxytocin immunoreactivity in the testis and that this oxytoc in is involved in modulating seminiferous tubule movements and the resultant sperm transport.
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34 Citations1983W.B. Watkins
Antisera raised against neurophysin, oxytocin and vasopressin were used, in conjunction with the immunofluorescence procedure, to localize the neuropeptides in corpora luteal tissue collected from sheep at estrus.
Journal of EndocrinologyCharacterization of endometrial and myometrial oxytocin receptors in the non-pregnant ewe
29 Citations1989V. J. Ayad, D.C. Wathes
The results suggest that oxytocin receptors present in the endometrium and myometrium of the ewe are similar both to each other and to classical oxytocIn receptors.
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29 Citations1988MR Luck, B. Jungclas
G granulosa cells secrete oxytocin according to an inherent time-schedule and that there is a limited period during which they can respond to ascorbate, which suggests that the availability of asCorbate during corpus luteum formation may determine the amount of oxytoc in response to catecholamines.
Journal of EndocrinologyVasopressin-neurophysin II gene expression in the ovary: studies in Sprague–Dawley, Long–Evans and Brattleboro rats
29 Citations1985Peter J. Fuller, Judith A. Clements +4 more
Using a synthetic pentadecamer nucleotide probe, highly specific for the 5' region of rat neurophysin II (NP II), the presence of AVP-NP II mRNA in the ovary of Sprague-Dawley, Long-Evans and Brattleboro rats is demonstrated, suggesting that tissue-specific differences in AVP -NP II gene expression occur at the translational as well as transcriptional level.
Journal of EndocrinologyLH and testosterone cause the development of seminiferous tubule contractile activity and the appearance of testicular oxytocin in hypogonadal mice
28 Citations1986HD Nicholson, R. T. S. Worley +2 more
The results support the evidence that testicular oxytocin modulates seminiferous tubule movements and suggest that testosterone may play a part in the accumulation of Oxytocin in the testis.
Journal of EndocrinologyLong-term and constant release of vasopressin from Accurel tubing: implantation in the Brattleboro rat
28 Citations1983Gerard J. Boer, J. Kruisbrink +1 more
The potency of the preparation is shown in vivo after subcutaneous implantation in the adult vasopressin-deficient Brattleboro rat, for which normal levels of urine production and osmolality were achieved at least for 1 month.
NeuropeptidesArginine vasopressin and oxytocin in the porcine corpus luteum
27 Citations1988V.J. Choy, W.B. Watkins
The relationship between ovarian oxytocin, vasopressin and progesterone, was determined in porcine corpora lutea collected at various stages of the estrous cycle and the presence of OT is confirmed, indicate the dominant presence of AVP and suggest that both hormones may be involved in Porcine CL function.
Current topics in neuroendocrinologyOxytocin as an Ovarian Hormone
26 Citations1986D.C. Wathes, R. W. Swann +2 more
The synthesis, secretion and actions of hypothalamic oxytocin are covered extensively in the rest of this volume, but a number of recent reports have confirmed an earlier observation that the corpus luteum also contains a hormone with an oxytocic action.
Cell and Tissue ResearchOxytocin in Leydig cells: an immunocytochemical study of Percoll-purified cells from rat testes
25 Citations1988W.S.B. Yeung, S. E. F. Guldenaar +3 more
Measurement of basal testosterone production, histo-enzymological staining for 3β-hydroxysteroid dehydrogenase activity and electron microscopy indicated that the majority of Ley dig cells were found in fraction IV, indicating that the Leydig cells were also the oxytocin immunoreactive cells.
EndocrinologyInhibitory Effect of Oxytocin and Vasopressin on Steroid Release by Cultured Porcine Luteal Cells*
25 Citations1988L. Pitzel, Irmelin Probst +2 more
Calculation of the ED50 data from dose-response curves of both peptides show that AVP is about 10(4)-fold more active than OXT in inhibiting in vitro progesterone and androstenedione secretion, which suggests that A VP as well as OXT may play an important role in the regulation of ovarian function.
Fertility and SterilityAntigonadotropic effect of oxytocin on the isolated human corpus luteum
25 Citations1987Barbro Bennegård, Mats Hahlin +1 more
In vitro data suggest a role for OT in the luteolytic process of humans and show that under certain experimental conditions, OT counteracted the stimulatory effect of hCG on both cAMP and P formation.
ReproductionEffect of active immunization against oxytocin on gonadotrophin secretion and the establishment of pregnancy in the ewe
24 Citations1989D.C. Wathes, V. J. Ayad +2 more
It is concluded that active immunization against oxytocin influences gonadotrophin secretion and reduces fertility and the site of action for both of these effects needs to be determined.
Journal of Dairy ScienceLuteal Function as Related to Pituitary and Ovarian Cytology and Embryo Development in the Bovine
24 Citations1961Robert Staples, Kathleen Mc Entee +1 more
Embryos recovered 15 days after insemination from 20 of 27 untreated Holstein heifers and those recovered from 18 of 43 heifer treated daily with 7 U.S.P. units of oxytocin per hundredweight per day did not differ in total length, embryonic disc size, or mesodermal development attained.
PubMedOvarian peptides in the cow and sheep.
23 Citations1989D. Schams
Treatment of heifers with progesterone for 4 days beginning after the LH surge shortens the oestrous cycle length significantly and there are indications for an intraovarian function of oxytocin influencing steroidogenesis by inhibition of progester one secretion.
Journal of EndocrinologyTwo vasopressin-like peptides in the pig testis?
19 Citations1988HD Nicholson, Andrew J. Smith +3 more
The presence of both LVP- and AVP-like peptides in the pig testis may mean that more than one gene is involved, and could also explain the anomalies of VP-IR in other species.
Journal of EndocrinologyOxytocin receptors in the oviduct during the oestrous cycle of the ewe
19 Citations1990V. J. Ayad, S. A. McGoff +1 more
It is concluded that oxytocin receptors are present in the Oviduct of the ewe around the time of ovulation, consistent with the existence of oviductal oxytocIn receptors which are regulated by ovarian steroids.
PubMedDelayed luteolysis and suppression of the pulsatile release of oxytocin after indomethacin treatment in the goat.
17 Citations1984R.G. Cooke, A.M. Homeida
Journal of EndocrinologyOXYTOCIN BIOSYNTHESIS IN SERUM-FREE CULTURES OF HUMAN GRANULOSA CELLS
17 Citations1990Ioannis Plevrakis, Christine Clamagirand +1 more
Journal of EndocrinologyDoes the human corpus luteum synthesize neurohypophysial hormones?
13 Citations1988Frederick J. Auletta, D. Stephen Charnock‐Jones +1 more
Animal Reproduction ScienceThe effect of oxytocin on progesterone secretion and of PGF2α on oxytocin secretion from bovine luteal and granulosa cells in culture
10 Citations1990J. Barrett, D.C. Wathes
Oxytocin had a variable effect on progesterone output from hCG-stimulated bovine luteal cells cultured for 12 h in vitro, suggesting that a limited amount of synthesis and/or processing was occurring in vitro.
Journal of MicroscopyA videomicrographic low‐frequency movement analyser (VLMA) and perifusion chamber for recording and analysis of the physical behaviour of seminiferous tubules and other contractile tissues <i>in vitro</i>
9 Citations1988R. T. S. Worley, JA Leendertz
A method has been developed for the recording and analysis of low frequency movements such as those of the surfaces of live seminiferous tubules, and the construction and features of the perifusion chamber used with the VLMA are described.
EndocrinologyHormonal Regulation of Rat Testicular Arginine Vasopressin Receptors*
8 Citations1989Barry G. Kasson, Tammy L. Tuchel
The data indicate that testicular AVP receptors are under the control of LH and GH from the pituitary and suggest that pituitsary hormones may impact on the efficacy of the testicle AVP system by regulating AVP receptor levels.
European Journal of EndocrinologyImmunohistochemical demonstration of oxytocin in the testis
7 Citations1986A. Weindl, BRAUN +1 more
Biochemical and Biophysical Research CommunicationsThe dynamics of the testosterone response of perifused mouse Leydig cells to hCG and Arginine Vasopressin
6 Citations1987A. Tahri-Joutei, Mathieu Latreille +1 more
The hypothesis of a possible role of neurohypophysial peptides on reproductive functions in the mouse by modulating steroidogenesis at the testicular level is supported by the finding that AVP acts directly on Leydig cells.
NeuropeptidesIsolation and sequence analysis of oxytocin from the sheep corpus luteum
4 Citations1986W.B. Watkins, V.J. Choy +2 more
This study represents the first identification by sequence analysis of oxytocin outside the central nervous system and established by Edman degradation and comparative reverse-phase HPLC its identity with hypothalamic Oxytocin.
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