Experimental Designs for Quadratic Models in Constrained Mixture Spaces

Abstract

The development of experimental designs for constrained mixtttre systems in which the response can be described by a qlladratic model is discussed. It is shown that efficient designs can be constructed from a srtbset of the vertices and centroids of the feasible region. For systems with five or more components, it is recommended that the Wynn and exchange algorithms be used to select a design from the available vertires and centroids. Illustrative examples are included.