Differential reactivity of dopaminergic neurons in the nucleus accumbens in response to different behavioral situations. An in vivo voltammetric study in free moving rats
Brain ResearchPublished 1 November 1986
Alain Louilot, Michel Le Moal, H. Simon
Citations168
SJR quartileQ2
SJR score0.85
SNIP0.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The reactivity of dopaminergic terminals in the nucleus accumbens was investigated in male rats submitted to tail-pinch or various social interactions and the greatest increase in dopamine activity was observed after the aggressive interaction.
Abstract
The reactivity of dopaminergic (DA) terminals in the nucleus accumbens was investigated in male rats submitted to tail-pinch or various social interactions. The DA activity was assessed by measurement of the presynaptic metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) by using differential pulse voltammetry in free moving preparations. Tail-pinch lasting 5 min or 10 min was followed by increases in DA activity of 25% and 35%, respectively. Three types of social interaction were used: interaction with an aggressive male congener, interaction with a non-aggressive male congener or interaction with a female congener. The greatest increase in dopaminergic activity (40%) was observed after the aggressive interaction. The reactivity of the DA neurons within the nucleus accumbens is, therefore, dependent on the characteristics of the behavioral situation.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
The Journal of Comparative NeurologyCatecholamine innervation of the basal forebrain IV. Topography of the dopamine projection to the basal forebrain and neostriatum
1,164 Citations1978James H. Fallon, Robert Y. Moore
The topography of the DA neuron projection on the basal forebrain and neostriatum is organized in three planes, dorsal‐ventral, medial‐lateral and anterior‐posterior, consistent with the view that the DA neurons of the SN‐VTA complex form a single nuclear group with a highly topographically organized projection innervating not only deep nuclei of the telencephalon but allocortical structures as well.
European Journal of PharmacologyEffects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity
567 Citations1976Annick Pijnenburg, Wiel Honig +2 more
D-Amphetamine proved more effective than dopamine in producing locomotor stimulation, whereas both stimulant and depressant effects were observed following injection of apomorphine into the nucleus accumbens.
Behavioral BiologyAggressive behavior in the rat
548 Citations1977Robert J. Blanchard, D. Caroline Blanchard
Examination of specific behaviors obtained in “aggression,’ “fighting,” or “dominance” tasks suggests that no commonly employed psychological test provides an adequate measure of intraspecific attack behavior.
NatureIn vivo electrochemical detection of catechols in the neostriatum of anaesthetized rats: dopamine or DOPAC?
417 Citations1980François Gonon, Michel Buda +3 more
The DPV method used in conjunction with an electrochemical treatment of this electrode yields stable and reproducible peaks in which catecholamines and AA are resolved from each other, suggesting that the technique may be a useful means of following dopaminergic activity in vivo.
Analytical ChemistryElectrochemical treatment of pyrolytic carbon fiber electrodes
404 Citations1981François Gonon, C. M. Fombarlet +2 more
Brain ResearchEfferents and afferents of the ventral tegmental-A10 region studied after local injection of [3H]leucine and horseradish peroxidase
404 Citations1979Hervé Simon, Michel Le Moal +1 more
The efferents and the afferents of the VMT-A10 region were studied by using anterograde ([3H]leucine) and retrograde (HRP) tracing techniques and it is shown that descending dopaminergic projections from the A10 neurones have been demonstrated.
Analytical ChemistryNormal pulse polarography with carbon fiber electrodes for in vitro and in vivo determination of catecholamines
335 Citations1979Jean Luc. Ponchon, Raymond Cespuglio +3 more
PsychopharmacologyInhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat
334 Citations1975Annick Pijnenburg, Wiel Honig +1 more
The results confirm the significance of dopaminergic mechanisms for the locomotor stimulant effect of d-amphetamine and indicate that the mesolimbic dopamine system plays an important role in this respect.
Brain ResearchVoltammetry in the striatum of chronic freely moving rats: Detection of catechols and ascorbic acid
279 Citations1981François Gonon, Michel Buda +2 more
It is confirmed that the catechol compound electrochemically detected in the striatum is the direct metabolite of the DA, i.e. DOPAC, and support the thesis of a functional relationship between AA levels and dopaminergic neurotransmission.
Brain ResearchBehavioral correlates of dopaminergic unit activity in freely moving cats
263 Citations1983George F. Steinfels, James Heym +2 more
D dopaminergic neurons maintain a remarkably constant rate and pattern of firing across a variety of behaviors and states, however, this stability can be dramatically altered under special circumstances, such as during and following orienting responses.
ScienceRegional Brain Dopamine Metabolism: A Marker for the Speed, Direction, and Posture of Moving Animals
194 Citations1985Curt R. Freed, Bryan K. Yamamoto
Dopamine metabolism in the nucleus accumbens was more strongly linked to the speed and direction of movement, while in the caudate nucleus dopamine and 3,4-dihydroxyphenylacetic acid were affected most by posture and direction.
NatureNigral and striatal dopamine release under sensory stimuli
171 Citations1977A. Nieoullon, A. Chéramy +1 more
The effects of unilateral sensory stimulations on the release of DA from nerve terminals and dendrites of the two nigrostriatal dopaminergic pathways are presented.
Behavioral and Neural BiologyAlternation behavior, spatial discrimination, and reversal disturbances following 6-hydroxydopamine lesions in the nucleus accumbens of the rat
143 Citations1985Khalid Taghzouti, Alain Louilot +3 more
It is suggested that the nucleus accumbens plays an important role in the transition of motivation into action, and that dopamine has a facilitatory influence on the mediation of these processes.
Brain ResearchModulation of dopaminergic activity in the nucleus accumbens following facilitation or blockade of the dopaminergic transmission in the amygdala: a study by in vivo differential pulse voltammetry
140 Citations1985Alain Louilot, H. Simon +2 more
Using in vivo voltammetry, dopaminergic activity in the nucleus accumbens (ACC) was assessed following microinjection of DAergic agonists and antagonists in the amygdala (AMY).
NeuroscienceChanges in monoamine metabolites measured by simultaneousin vivo differential pulse voltammetry and intracerebral dialysis
118 Citations1984Trevor Sharp, Nigel T. Maidment +5 more
A close correlation between changes in extracellular 3,4-dihydroxyphenylacetic acid and its respective voltammetric peak is shown and strongly support the use of in vivo differential pulse voltammetry for monitoring dopamine metabolism.
Brain ResearchBehavioral study after local injection of 6-hydroxydopamine into the nucleus accumbens in the rat
109 Citations1985Khalid Taghzouti, H. Simon +3 more
The behavioral effects of destruction of the dopaminergic innervation of the nucleus accumbens are investigated to suggest that the n.Acc.
Brain ResearchSubstantia nigra dopaminergic unit activity in behaving cats: Effect of arousal on spontaneous discharge and sensory evoked activity
107 Citations1985Robert E. Strecker, Barry L. Jacobs
The lack of responsiveness of these neurons to a variety of arousal/stress manipulations supports the hypothesis that dopaminergic neurons play a permissive, rather than an active, role in these processes.
Brain ResearchEnvironmental stimuli but not homeostatic challenges produce apparent increases in dopaminergic activity in the striatum: An analysis by in vivo voltammetry
95 Citations1983Richard W. Keller, Edward M. Stricker +1 more
Using in vivo voltammetry in rats, the relationship between the electrochemical signal measured in the striatum and the behavioral responses associated with various types of stimulation was examined, suggesting that the signal observed was associated with an increase in the activity of central dopaminergic neurons.
Brain ResearchSilver impregnation of dopaminergic systems after radiofrequency and 6-OHDA lesions of the rat ventral tegmentum
90 Citations1976Hervé Simon, Michel Le Moal +2 more
The limbic forebrain cortical projections of the A10 group provide a coherent anatomical basis for the behavioral syndrome provoked by RF and 6-OHDA lesions in the VMT.
Brain ResearchReciprocal influences of activating and immobilizing stimuli on the activity of nigrostriatal dopamine neurons
71 Citations1979Louis A. Chiodo, Anthony R. Caggiula +2 more
Brain Research BulletinEffects of peripheral stimulation on the activity of neurons in the ventral tegmental area, substantia nigra and midbrain reticular formation of rats
56 Citations1982Hisao Maeda, Gordon J. Mogenson
Brain ResearchAsymmetric dopamine and serotonin metabolism in nigrostriatal and limbic structures of the trained circling rat
55 Citations1984Bryan K. Yamamoto, Curt R. Freed
The results show that extrapyramidal and limbic dopamine and serotonin metabolism are involved in turning behavior of normal animals and multiple transmitters of the nigrostriatal pathway and the limbic system appear to interact to modulate voluntary circling behavior.
ScienceTail-Pinch Stimulation: Sufficient Motivation for Learning
53 Citations1976George F. Koob, P.J. Fray +1 more
A paper clip applied to the tails of rats induced gnawing and eating, which decreased in latency and increased in duration with experience, supporting the hypothesis that a nonspecific arousing stimulus can be a sufficient condition for establishing learned habits.
Acta Pharmacologica et ToxicologicaExploratory and Socio‐Sexual Behaviour in the Male Laboratory Rat: A Methodological Approach for the Investigation of Drug Action
52 Citations1981Bengt J. Meyerson, A. Urban Höglund
The data show that simultaneous recording of several spontaneous behaviours may be a useful technique for investigating how a compound influences behavioural processes.
Brain ResearchEffects of d- and l-amphetamine on dopamine metabolism and ascorbic acid levels in nucleus accumbens and olfactory tubercle as studied by in vivo differential pulse voltammetry
40 Citations1985Alain Louilot, François Gonon +4 more
Differential pulse voltammetry used together with electrochemically pretreated carbon fibre microelectrodes allowed us to detect in vivo two well-separated peaks in nucleus accumbens and olfactory tubercle and D-amphetamine was more effective than L-amphetamine in increasing peak 1 height.
NeuroscienceEffect of haloperidol and sulpiride on dopamine metabolism in nucleus accumbens and olfactory tubercle: A study by in vivo voltammetry
31 Citations1985Alain Louilot, Michel Buda +4 more
The main conclusions of this study are that the results of voltammetry agree with biochemical results on the effects of haloperidol and sulpiride on dopamine metabolism.
PubMedVoltammetry in vivo: effect of stressful manipulations and drugs on the caudate nucleus of the rat [proceedings].
23 Citations1979G. Curzon, P.H. Hutson +1 more
Evidence is provided that the active conformation of dopamine at Helix dopamine receptors is the extended form (1rotamer), and the possibility that sulpiride might act, not at the recognition site of the dopamine receptor, but at some other site such as an ionophore is suggested.