Cycle‐Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro‐oxidation, and Amino‐oxidation, and to Natural Product Synthesis
Angewandte Chemie International EditionPublished 11 May 2009Open access
Bryon Simmons, Abbas M. Walji, David W. C. MacMillan
Citations276
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TL;DR
The combined application of iminium (Im) and enamine (En) catalysts can effect a range of valuable asymmetric transformations including 1,2-hydroamination, -hydro-oxidation, and -amino-Oxidation of olefins.
Abstract
United in effort: The combined application of iminium (Im) and enamine (En) catalysts can effect a range of valuable asymmetric transformations including 1,2-hydroamination, -hydro-oxidation, and -amino-oxidation of olefins (see picture). An enantioselective organocascade catalysis was also applied in the synthesis of a complex natural product.
Keywords
Chemistry
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