Anticoagulants in Myocardial Infarction
BMJPublished 1 February 1958Open access
M. Toohey
Citations21
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Keywords
Medicine
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Age and sex have hitherto received less consideration than they merit in publications dealing with prognosis and mortality in coronary artery disease, and a clear knowledge of all factors that influence mortality is of paramount importance at a time when the efficicacy of modern methods of treatment is under critical review.
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The beneficial effects of anticoagulant therapy in myocardial infarction were most apparent in the "poor risk" group of patients and then chiefly so in those less severely ill and cannot be entirely ascribed to a reduction in thromboembolic phenomena.
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Analysis of the causes of death did not yield evidence that anticoagulant therapy would have reduced the mortality to a significant degree, but the mortality for the good-risk patients was in marked contrast to the mortality of 60% previously found for poor- risk patients.
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It is satisfactory to record at the outset that the days of "' masterly inactivity" are being gradually replaced by a positive therapeutic programme which has halved the mortality rate and which opens the way to further endeavours on behalf of these patients.
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Series of patients with myocardial infarction treated with anticoagulants have generally shown a decrease in death rate of one-third to one-half that seen in series of such patients on other types of treatment.
