Changes in paracetamol, antidepressants and opioid poisoning in Scotland during the 1990s
QJMPublished 1 February 2003Open access
D. Nicholas Bateman
Citations48
SJR quartileQ3
SJR score0.40
SNIP0.43
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Overall discharge rates increased until 1997, after which they fell, and a pattern was seen in paracetamol-related discharges, but not for antidepressants or for opioids, which was more common in females, except for opioids.
Abstract
Increases in opioid-related presentations are of major concern. Changes in paracetamol pack-size have been associated with reduced discharge rates. In Scotland the age group with the highest rate of discharge (15-24 years) with paracetamol overdose is not the one with the highest mortality.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
BMJEffects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study
382 Citations2001Keith Hawton, Ellen Townsend +5 more
Legislation restricting pack sizes of paracetamol and salicylates in the United Kingdom has had substantial beneficial effects on mortality and morbidity associated with self poisoning using these drugs.
The British Journal of PsychiatryParacetamol Self-Poisoning Characteristics, Prevention and Harm Reduction
146 Citations1996Keith Hawton, Christopher J. G. Ware +5 more
Establishing a maximum number of tablets (e.g. 25) that can be available in individual preparations is likely to reduce the dangers of paracetamol self-poisoning.
The LancetChange in occurrence of paracetamol overdose in UK after introduction of blister packs
107 Citations2000JL Turvill, A BURROUGHS +1 more
BMJRegular review: Management of patients who deliberately harm themselves
100 Citations2001Göran Isacsson
Patients who deliberately harm themselves should be assessed as comprehensively and thoroughly as possible, including the risk for suicide, and a multidisciplinary team approach to assessment and management is optimal.
The British Journal of PsychiatrySuicide among drug addicts in the UK
74 Citations1999Adenekan Oyefeso, Hamid Ghodse +2 more
The findings confirm that addicts are still at higher risk of suicide than the general population and that prescribed drugs, notably antidepressants and methadone, influence this heightened risk.
The LancetReduction in incidence of severe paracetamol poisoning
70 Citations2000Martin I. Prince, Simon HL Thomas +2 more
There are substantial reductions in the frequency of severe paracetamol hepatotoxicity locally and nationally after legislative limitations on its sale.
The British Journal of PsychiatryHospitalisation for Deliberate Self-Poisoning in Scotland from 1981 to 1993: Trends in Rates and Types of Drugs Used
56 Citations1996Philip McLoone, Iain K. Crombie
Rapid increases in self-poisoning particularly among young adults present a serious public health problem and is made difficult because the principal drug involved, paracetamol, is readily available.
BMJSeverity of overdose after restriction of paracetamol availability: retrospective study
41 Citations2000D. Robinson
The impact of reduced availability of paracetamol on the number and severity of overdoses is assessed by comparing self poisoning cases in two periods of six months before and after the change to smaller packets.
The LancetReferral patterns and social deprivation in paracetamol-induced liver injury in Scotland
29 Citations2001Philip N. Newsome, Andrew Bathgate +8 more
It is shown that patients admitted to the Scottish Liver Transplantation Unit in 1992-98 with those admitted in 1998-2001 had higher Carstairs scores, and an association between paracetamol-induced acute liver failure and social deprivation is shown.
Human & Experimental ToxicologyParacetamol poisoning in the North East of England: presentation, early management and outcome
29 Citations1997Shl Thomas, JE Horner +12 more
Most cases do not have potentially toxic plasma paracetamol concentra tions, but those who do often present late and antidotal treatment may be delayed inappropriately.