Melatonin effect on daytime sleep in men: suppression of EEG low frequency activity and enhancement of spindle frequency activity
Neuroscience LettersPublished 1 December 1995
Derk‐Jan Dijk, Corinne Roth, Hans‐Peter Landolt, Esther Werth, Michael Aeppli, Peter Achermann
Citations135
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
Changes in the EEG are to some extent similar to those induced by benzodiazepine hypnotics and to the contribution of the endogenous circadian pacemaker to the spectral composition of the sleep EEG when sleep occurs at night.
Abstract
The effect of melatonin (5 mg, p.o.) on electroencephalographic (EEG) activity during sleep was investigated in eight men in a placebo-controlled cross-over design. Melatonin was administered immediately prior to a 4-h daytime sleep episode (13-17 h) after a partial sleep deprivation. The non-REM sleep stages and REM sleep duration were not significantly affected. Melatonin enhanced EEG power density in non-REM sleep in the 13.75-14.0 Hz bin (i.e., within the frequency range of sleep spindles), and reduced activity in the 15.25-16.5 Hz band. In the first 2 h spectral values within the 2.25-5.0 Hz range were reduced. These changes in the EEG are to some extent similar to those induced by benzodiazepine hypnotics and to the contribution of the endogenous circadian pacemaker to the spectral composition of the sleep EEG when sleep occurs at night.
Keywords
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