Increased breath biomarkers of oxidative stress in diabetes mellitus
Clinica Chimica ActaPublished 29 May 2004
Michael Phillips, Renee N. Cataneo, Taseer Cheema, Joel Greenberg
Citations200
SJR quartileQ1
SJR score0.91
SNIP1.00
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Oxidative age, a marker of oxidative stress, was significantly increased in both type 1 and type 2abetes mellitus, and merits further study as a candidate marker of risk for the complications of diabetes mellitus.
Abstract
Oxidative age, a marker of oxidative stress, was significantly increased in both type 1 and type 2 diabetes mellitus. Oxidative age merits further study as a candidate marker of risk for the complications of diabetes mellitus.
Keywords
Biochemistry, Genetics and Molecular BiologyNursingEngineering
Diabetic MedicineRadicals and oxidative stress in diabetes
918 Citations2000Ian C. West
It is argued that oxygen, antioxidant defences, and cellular redox status should now be regarded as central players in diabetes and the metabolic syndrome.
Diabetes/Metabolism Research and ReviewsThe role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
876 Citations2001P. R�sen, PP Nawroth +4 more
This review summarises the results and discussions of an UNESCO‐MCBN supported symposium on oxidative stress and its role in the onset and progression of diabetes and suggests a role for ROI in the development of insulin resistance.
Journal of Chromatography B Biomedical Sciences and ApplicationsVariation in volatile organic compounds in the breath of normal humans
725 Citations1999Michael Phillips, Jolanta Herrera +4 more
Two new findings were the comparatively small variation in total number of breath VOCs, and the presence of a 'common core' of breathVOCs in all subjects.
PubMedConsequences of the diabetic status on the oxidant/antioxidant balance.
431 Citations2000Dominique Bonnefont‐Rousselot, J.-P. Bastard +2 more
The aim of this paper was to review the consequences of the diabetic status on the oxidant/antioxidant balance, and some antidiabetic agents may by themselves have antioxidant properties independently of their role on glucose control.
DiabetesXanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes
390 Citations2002Marí-Carmen Desco, Miguel Asensi +6 more
Free Radical Biology and MedicineThe potential of the hydrocarbon breath test as a measure of lipid peroxidation
372 Citations1994C. M. F. Kneepkens, Guy Lepage +1 more
The results of the hydrocarbon breath test are not influenced by prior food consumption, but both vitamin E and beta-carotene supplementation decrease hydrocarbon excretion, and the long-term use of a diet high in polyunsaturated fatty acids, such as in parenteral nutrition regimens, may result in increased hydrocarbon exhalation.
Analytical BiochemistryMethod for the Collection and Assay of Volatile Organic Compounds in Breath
360 Citations1997Michael Phillips
An improved breath-collecting apparatus (BCA) is described which was acceptable to patients, simple to use, highly sensitive, and free from chemical contamination.
Kidney InternationalReactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose
309 Citations2000Hunjoo Ha, Hi Bahl Lee
Evidence is provided that ROS generated by glucose metabolism may act as integral signaling molecules under HG as in other membrane receptor signaling, and signal transduction pathways linking HG, ROS, PKC, transcription factors, and extracellular matrix (ECM) protein synthesis in mesangial cells have not been fully elucidated.
PubMedFree radicals: their history and current status in aging and disease.
227 Citations1999Joseph A. Knight
There are extensive global basic research efforts to define more clearly the role of free radicals and oxidative stress in aging and various diseases as well as in numerous human diseases/disorders where they have either a primary or secondary role.
DiabetesDefective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.
208 Citations2000Antonio Ceriello, Anna Morocutti +5 more
Skin fibroblasts from diabetic patients without complications or from nondiabetic nephropathic patients have an intact antioxidant response to glucose-induced oxidative stress, confirming that exposure to high glucose concentrations induces an antioxidant defense in skin fibro Blasts from normal subjects.
Diabetes CareSerum markers of oxidative stress and severity of diabetic retinopathy.
163 Citations2000M. Elizabeth Hartnett, Ron Stratton +4 more
Increased levels of TBARS and decreased levels of SOD and GSH-Px were found in diabetic patients compared with those in control subjects, but no significant associations were found between the levels of these substances and severity of retinopathy when duration and type of diabetes and serum HbA1 levels were taken into account.
Journal of Laboratory and Clinical MedicineEffect of age on the breath methylated alkane contour, a display of apparent new markers of oxidative stress
159 Citations2000Michael Phillips, Renee N. Cataneo +4 more
The BMAC provides a display of apparent new markers of oxidative stress with potential applications in aging research, clinical diagnosis, pharmacology, and toxicology, although an age-related decline in clearance by cytochrome p450 may have contributed.
AtherosclerosisSerum paraoxonase is reduced in type 1 diabetic patients compared to non-diabetic, first degree relatives; influence on the ability of HDL to protect LDL from oxidation
129 Citations2001Massimo Boemi, Ilia Leviev +4 more
Serum concentrations of the antioxidant enzyme paraoxonase are significantly lower in type 1 (insulin-dependent) diabetic patients compared to non-diabetic, first-degree relatives, independently of known gene polymorphisms, consistent with the contention that modifications to serum paraox onase in type1 patients can increase risk of lipoprotein oxidation and, consequently, risk of vascular disease.
European Journal of Clinical InvestigationSerum paraoxonase activity in patients with type 1 diabetes compared to healthy controls
129 Citations2002Bharti Mackness, Paul N. Durrington +3 more
This work has shown that high‐density lipoprotein associated paraoxonase (PON1) can retard the oxidation of LDL, which is central to current theories on the initiation and progression of atherosclerosis.
European Respiratory JournalEffect of oxygen on breath markers of oxidative stress
124 Citations2002Michael Phillips, Renee N. Cataneo +4 more
Breath markers of oxidative stress were significantly increased in normal volunteers breathing supplemental oxygen for 30 min, and there was a significant increase in mean volume under the curve of the BMAC and in alveolar gradients of three VOCs: 3‐methyltridecane, 3-methylundecane and 5-methylnonane.
Journal of Internal MedicineOxidative stress and antioxidant status in type 1 diabetes mellitus
120 Citations2002Johan Vessby, Soumen Basu +3 more
Oxidative stress and antioxidant status in type 1 diabetes mellitus is studied to assess the role of oxidative stress and its role in disease progression.
CHEST JournalExhaled Carbon Monoxide Levels Elevated in Diabetes and Correlated With Glucose Concentration in Blood
118 Citations1999Paolo Paredi, W Biernacki +3 more
American Journal of Obstetrics and GynecologyIncreased breath markers of oxidative stress in normal pregnancy and in preeclampsia
95 Citations2004Michael Moretti, Michael Phillips +3 more
A breath test significantly demonstrated greater oxidative stress in women with preeclampsia than in uncomplicated pregnancy and nonpregnant control subjects.
PubMedThe hydrocarbon breath test in the study of lipid peroxidation: principles and practice.
90 Citations1992C. M. F. Kneepkens, Chryslen Brenda da Silva Ferreira +2 more
The hydrocarbon breath test provides a noninvasive and extremely sensitive instrument for the assessment of oxidative stress status in adults as well as in children.
DiabetologiaDiabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product N e -(carboxymethyl) lysine independently of glycohaemoglobin concentrations
84 Citations1999HP Hammes, M. Brownlee +3 more
Diabetes Research and Clinical PracticeMetabolic control quality and free radical activity in diabetic patients
77 Citations1995Bogna Wierusz‐Wysocka, Henryk Wysocki +4 more
The results seem to confirm the previous suggestions concerning the relation between metabolic disturbances and oxidative stress in diabetic patients.
BMC Medical GeneticsPolymorphisms in the Mn-SOD and EC-SOD Genes and Their Relationship to Diabetic Neuropathy in Type 1 Diabetes Mellitus
68 Citations2001D. A. Chistyakov, Kirill V. Savostyanov +2 more
Ala(-9)Val substitution in the Mn-SOD gene was associated with DN in a Russian population and a new polymerase chain reaction (PCR) assays for rapid detection of polymorphisms were developed and used.
Journal of the American College of CardiologyEndothelial vasodilator function is related to low-density lipoprotein particle size and low-density lipoprotein vitamin E content in type 1 diabetes
66 Citations2000R. Andrew P. Skyrme-Jones, Richard O’Brien +2 more
PubMedIn vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy.
64 Citations2000L Androne, Norina A. Gâvan +2 more
The antioxidant therapy with LA improves and may prevent diabetic neuropathy and is associated with a reduction in the indexes of lipid peroxidation.
Clinica Chimica ActaIncreased oxidative stress in younger as well as in older humans
52 Citations2003Michael Phillips, Renee N. Cataneo +3 more
Breath markers of OS were significantly increased both in younger and in older subjects, compared to those aged 20-40 years, suggesting this may be a normal physiological response in youth.