Pharmacokinetics, safety, and tolerability of varenicline in healthy adolescent smokers: A multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Clinical TherapeuticsPublished 1 January 2009
Hélène M. Faessel, Patanjali Ravva, Kathryn Williams
Citations68
SJR quartileQ1
SJR score0.98
SNIP1.02
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TL;DR
Varenicline steady-state exposure in study subjects weighing >55 kg was similar to that observed previously in adults, and the body-weight effect on vareniclines pharmacokinetics resulted in higher exposure in individuals of smaller body size.
Abstract
Varenicline steady-state exposure in study subjects weighing >55 kg was similar to that observed previously in adults. The body-weight effect on varenicline pharmacokinetics, which resulted in higher exposure in individuals of smaller body size (< or =55 kg), was adequately offset by administration of half the varenicline dose recommended in adults. Varenicline was generally well tolerated during the 14-day treatment period. Clinical Trials Identification Number: NCT00463918.
Keywords
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