Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults
Biological PsychiatryPublished 3 June 2008Open access
Anna L. Marsland, Peter J. Gianaros, Sarah M. Abramowitch, Stephen B. Manuck, Ahmad R. Hariri
Citations347
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TL;DR
This is the first report of a relationship between a peripheral marker of IL-6 and hippocampal grey matter volume, raising the possibility that low-grade systemic inflammation could plausibly presage subclinical cognitive decline in part via structural neural pathways.
Abstract
To our knowledge, this is the first report of a relationship between a peripheral marker of IL-6 and hippocampal grey matter volume, raising the possibility that low-grade systemic inflammation could plausibly presage subclinical cognitive decline in part via structural neural pathways.
Keywords
Neuroscience
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The authors would like to correct the following phrase on page 607, second column, lines 6–7 from bottom: ‘However, IL-1β concomitantly appears in the basolateral amygdala, where neuronal IL- 1 receptors are present’.