Reexamination of Glucose-6-Phosphatase Activity in the Brain in Vivo: No Evidence for a Futile Cycle
SciencePublished 5 July 1985Open access
Thomas J. Nelson, Giovanni Lucignani, Steven A. Atlas, Alison M. Crane, Gerald A. Dienel, Louis Sokoloff
Citations83
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose- 6-ph phosphatase activity in the brain.
Abstract
Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.
Keywords
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