The relationship of obsessive–compulsive disorder to possible spectrum disorders: results from a family study
Biological PsychiatryPublished 1 August 2000
O. Joseph Bienvenu, Jack Samuels, Mark A. Riddle, Rudolf Hoehn‐Saric, Kung‐Yee Liang, Bernadette Cullen
Citations557
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
Findings indicate that certain somatoform and pathologic grooming conditions are part of the familial OCD spectrum, though other "spectrum" conditions may resemble OCD, and they do not appear to be important parts of the family spectrum.
Abstract
These findings indicate that certain somatoform and pathologic grooming conditions are part of the familial OCD spectrum. Though other "spectrum" conditions may resemble OCD, they do not appear to be important parts of the familial spectrum.
Keywords
Psychology
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458 Citations1970John Cooper
The construction and development of an inventory of 69 questions dealing with the subjective assessment of obsessional traits and symptoms is described, and the resulting scores are shown to differentiate well between a group of selected obsessional patients and normals.
Journal of Psychiatric ResearchSchedule for Affective Disorders and Schizophrenia—Lifetime version modified for the study of anxiety disorders (SADS-LA): Rationale and conceptual development
397 Citations1986Salvatore Mannuzza, Abby J. Fyer +2 more
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PubMedObsessive compulsive spectrum disorder.
321 Citations1994S L McElroy, K A Phillips +1 more
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Journal of the American Academy of Child PsychiatryThe Leyton Obsessional Inventory-Child Version
263 Citations1986Carol J. Berg, Judith L. Rapoport +1 more
American Psychiatric Press eBooksObsessive-compulsive-related disorders
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